Search Results

3 results

  1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 31

    Improvement of in-situ slide preparation procedure for semi-automated micronucleus counting system

    ERAMI K.(1); SAWAMOTO Y.(1); YOSHINO K.(1); SOFUNI T.(2)
    (1) Japan Tobacco Inc., Scientific Product Assessment Center, Yokohama, Kanagawa, Japan; (2) Genotoxic Consulting Services, Shiraoka, Saitama, Japan
    In-situ micronucleus (MN) test is an easier-to-use procedure than the traditional way such as a dish preparing approach. Nevertheless, the amount of resources needed for manual counting and the necessity of advanced preparations for reaching consensus of ...
  2. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 16

    Loss of heterozygosity analysis of Tk mutants induced by cigarette smoke condensates and their chemical components in L5178Y mouse lymphoma cells

    KANEMARU Y.; SAWAMOTO Y.; TANAKA H.; FUKUSHIMA T.; SOFUNI T.
    Japan Tobacco Inc., Tobacco Science Research Center, Yokohama, Kanagawa, Japan
    For the testing of tobacco smoke genotoxicity in mammalian cells, CORESTA In Vitro Toxicity Testing of Tobacco Smoke Task Force recommends the micronucleus assay (MN), chromosome aberration assay or L5178Y mouse lymphoma assay (MLA). These three assays ...