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3 results

  1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 29

    Establishment of a respiratory parameter measurement system for mice using an unrestrained whole-body plethysmograph

    SUZUKI H.; MOTOHASHI Y.; OZAKI H.; MINE T.
    Japan Tobacco Inc., R&D Group, Scientific Product Assessment Center, Yokohama, Kanagawa, Japan
    Respiratory parameters, such as tidal volume (TV), breathing frequency (Bf) and minute volume (MV), are important factors in the evaluation of the effect of cigarette smoke (CS) on laboratory animals in in vivo inhalation studies. However, a measurement ...
  2. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 30

    Comparative study of cigarette smoke-induced effects among multiple strains of mice

    MOTOHASHI Y.; SUZUKI H.; OZAKI H.; MINE T.
    Japan Tobacco Inc., R&D Group, Scientific Product Assessment Center, Yokohama, Kanagawa, Japan
    It is known that the effects of cigarette-smoke (CS) exposure on mice are strain-dependent, due to differences in genetic backgrounds. However, the susceptibility of the strains to CS-exposure is inconsistent across reports, probably because of ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2013, Seville, ST 41

    Activation of transcription factors in human bronchial epithelial cells exposed to aqueous extracts of mainstream cigarette smoke in vitro

    SEKINE T.; HIRATA T.; MINE T.; FUKANO Y.
    Japan Tobacco Inc., Product Science Division, R&D Group, Yokohama, Japan
    Transcription factors are recognised as important components of signalling cascades controlling all types of normal cellular processes as well as response to external stimulus. Activation of transcription factors can alter the expression of specific genes ...