Search Results

16 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 18

    Human precision-cut lung slices as a screening tool: increased throughput, cryopreservation, and detection of DNA adducts for next generation tobacco product evaluation

    BEHRSING H.P.(1); DESAI P.(1); AMIN K.(2); BALBO S.(3); HECHT S.S.(2); SHEEHAN D.(1); CASTRO N.(1); ALLEN D.(4)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Division of Environmental Health Sciences, Minneapolis, MN, U.S.A.; (3) University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, U.S.A.; (4) Integrated Laboratory Systems, Inc., Morrisville, NC, U.S.A.
    Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the many chemicals requiring hazard assessment, such as next generation tobacco product (NGTP) ingredients. Human precision-cut lung...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 36

    Use of ex vivo precision-cut lung slices as a screening tool for potential respiratory toxicity of e-liquids

    BEHRSING H.P.(1); SHEEHAN D.(1); AMIN K.(2); LEE K.M.(3); OLDHAM M.(4); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Minneapolis, MN, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) former Altria Client Services employee
    The Family Smoking Prevention and Tobacco Control Act gave the FDA regulatory authority over next generation tobacco products (NGTP) such as e-vapor products. E-vapor product liquids contain a variety of ingredient combinations that should be...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 47

    Identification, discussion and recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    DESAI P.(1); CURREN R.(1); MOORE M.M.(2)
    (1) Institute for In Vitro Sciences, Gaithersburg, MD, U.S.A.; (2) Ramboll Environ Inc., Little Rock, AR, U.S.A.
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 008

    Workshop series to identify, discuss and develop recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    MOORE M.M.(1); CURREN R.(2)
    (1) Ramboll US Corporation, Little Rock, AR, USA; (2) Institute for In Vitro Sciences, Gaithersburg, MD, USA
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco...
  5. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 33

    Accurate and reproducible dispensing of patterned picoliter quantities of tobacco extract onto apical surfaces of human 3D reconstructed airway tissues

    BEHRSING H.(1); SADOWSKI N.(1); CONSTANT S.(2); HUANG S.(2); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) Epithelix Sàrl, Geneva, Switzerland
    There is an increasing need for researchers to understand the dynamic aspects of inhaled tobacco product exposure. Exposure-induced events can cause respiratory irritation, sensitisation, and other events that may lead to severe pulmonary disease....
  6. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 109

    3d reconstructed human airway models: effect of acclimation conditions on biomarker and inflammatory response following tissue challenge

    BEHRSING H.; RAABE H.A.; SHEEHAN D.W.; SLY E.A.; CURREN R.D.
    Institute for In Vitro Sciences, Gaithersburg, MD USA
    Human reconstructed, 3-dimensional (3D) airway tissues present researchers with organotypic models that consist of heterogenous cell types that more accurately reflect the pulmonary airway in vivo. These in vitro models are now increasingly applied...
  7. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 15

    Evaluation of the EpiOral™ reconstructed human oral buccal tissue model as a testing platform for determining the oral irritation potential of tobacco products

    RAABE H.; BARNES N.; HILBERER A.
    Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.
    There is an increasing need by the tobacco industry to evaluate the oral/buccal irritation potential of tobacco products both to support product development goals and for sound product stewardship. The use of in vitro human cell and tissue-based test...
  8. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 05

    The use of precision-cut lung slices to assess inflammation, parenchymal damage, and collagen deposition: three markers of tobacco exposure-induced pulmonary toxicity

    BEHRSING H.P.
    Institute for In Vitro Sciences, Inc., Gaithersburg, Maryland, USA
    The Family Smoking Prevention and Tobacco Control Act (TCA) gives the Food and Drug Administration (FDA) broad authority to regulate tobacco products. The FDA-Center for Tobacco Products (CTP) calls for several research priority areas, including in...
  9. Bull. Spec. CORESTA Congress, Lisbon, 2000, p. 107, APOST6 (adjourned)

    Estimation of the state of nitrogen nourishment of tobacco using the N-tester

    KOWALCZYK-JUSKO A.; KOSCIK B.
    University of Agriculture, Lublin - Institute of Agricultural Sciences, Zamosc, Poland.
    The purpose of this work, based on a three years of field experiment, was to inspect whether it is possible to use a chlorophyll meter in fixing the nitrogen doses used in growing flue-cured tobacco. The relationship between the capacity of nitrogen...
  10. Bull. Spec. CORESTA Congress, Brighton, 1998, p. 112, APOST13

    Influence of aqua terra hydrogel on growth, development and yield of light cigarette tobacco

    KOSCIK B.; KOWALCZYK-JUSKO A.
    University of Agriculture, Lublin - Institute of Agricultural Sciences, Zamosc, Poland.
    The aim of introductory field and pot experiments which were carried out in Zamosc in the years of 1995-1997 was to study the influence of Aqua Terra hydrogel on the growth, development and yield of light cigarette tobacco. Hydrogels are substances...