Search Results

15 results

  1. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 25

    Human abuse liability assessment of tobacco and nicotine products: considerations to meet current regulatory recommendations

    BAXTER S.(1); VANSICKEL A.(2); SHERWOOD N.(3); CAMPBELL L.(1); KONG M.(4)
    (1) RAI Services Company, Winston Salem, NC, U.S.A.; (2) Altria Client Services, Richmond, VA, U.S.A.; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) Altasciences Clinical Research, Laval, QC, Canada
    The U.S. Food and Drug Administration (FDA) recommends that tobacco product manufacturers provide information regarding the abuse liability of tobacco and nicotine-containing products to support pre-market tobacco, modified risk tobacco product and...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 12

    Review of current methodologies in evaluating abuse liability of nicotine and tobacco products in the U.S. regulatory environment

    EVANS S.(1); KONG M.C.(2); CAMPBELL L.(2); SHERWOOD N.(3); PRASAD K.(4)
    (1) Turning Point Brands, Louisville, KY, U.S.A.; (2) Altasciences Clinical Research, Laval, Canada; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) British American Tobacco, R&D, Millbrook, Southampton, U.K.
    Traditional definitions of abuse and misuse do not apply to a consumer product such as tobacco that consumers essentially use ‘as intended’. In contrast to pharmaceutical products, a guidance for abuse liability testing of nicotine and tobacco...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 52 (also presented at TSRC 2019)

    Application of differential ion mobility spectrometry-tandem mass spectrometry for improved assay selectivity and sensitivity in the quantitation of tobacco biomarkers NNN, NNAL and 2-/3-HPMA in human urine

    PLOMLEY J.B.
    Altasciences, Laval, QC, Canada
    Differential ion mobility spectrometry (DMS) has recently emerged as an orthogonal gas-phase ion separation technique which, when interfaced between liquid chromatography (LC) and tandem mass spectrometry (MS/MS), promises improvements in both assay...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 044

    Abuse liability of very low nicotine content cigarettes with characterization of nicotine exposure profiles in adult smokers

    LEVY-COOPERMAN N.(1); SHRAM M.J.(1); KELSH D.(2); VINCE B.(2); CARMINES E.(3)
    (1) Altreos Research Partners, Toronto, ON, Canada; (2) Altasciences/Vince and Associates, Overland Park, KS, USA; (3) Carmines Consulting, Scottsdale, AZ, USA
    Objectives: In 2017, FDA announced the intention to explore limiting nicotine in cigarettes to minimal/non-addictive levels. Research indicates that reduced nicotine content would potentially limit reinforcing effects of cigarettes. We conducted 2...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 102 (also presented at CORESTA SSPT2019)

    Novel application of differential ion mobility spectrometry-tandem mass spectrometry for improved assay selectivity and sensitivity in the quantitative determination of total NNN total NNAL and 2- / 3-HPMA in human urine

    PLOMLEY J.
    Altasciences, Laval, Canada
    Differential Ion Mobility Spectrometry (DMS) has recently emerged as an orthogonal gas-phase ion separation technique which, when interfaced between liquid chromatography (LC) and Tandem Mass Spectrometry (MS/MS), promises improvements in both assay...
  6. Bull. Spec. CORESTA Congress, Lisbon, 2000, p. 107, APOST6 (adjourned)

    Estimation of the state of nitrogen nourishment of tobacco using the N-tester

    KOWALCZYK-JUSKO A.; KOSCIK B.
    University of Agriculture, Lublin - Institute of Agricultural Sciences, Zamosc, Poland.
    The purpose of this work, based on a three years of field experiment, was to inspect whether it is possible to use a chlorophyll meter in fixing the nitrogen doses used in growing flue-cured tobacco. The relationship between the capacity of nitrogen...
  7. Bull. Spec. CORESTA Congress, Brighton, 1998, p. 112, APOST13

    Influence of aqua terra hydrogel on growth, development and yield of light cigarette tobacco

    KOSCIK B.; KOWALCZYK-JUSKO A.
    University of Agriculture, Lublin - Institute of Agricultural Sciences, Zamosc, Poland.
    The aim of introductory field and pot experiments which were carried out in Zamosc in the years of 1995-1997 was to study the influence of Aqua Terra hydrogel on the growth, development and yield of light cigarette tobacco. Hydrogels are substances...