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41 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 049

    Assessment of in vitro toxicity/genotoxicity of ends and combustible products

    JORDAN K.(1); BOMBICK B.(1); COOPER B.(1); LEVERETTE R.(1); SHUTSKY T.(1); WEST C.(1); STRASSER J.(1); ROUND E.(1); MARANO K.M.(1); MOMIN R.(2); TRIVEDI A.(2); WAGSTAFF W.(2); BRUCE S.(3); DAKOULAS E.(3); ROY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labstat International ULC, Kitchener, ON, Canada; (3) BioReliance Corp, Rockville, MD, USA
    In May 2016, the U.S. Food and Drug Administration Center for Tobacco Products (CTP) issued draft guidance for Premarket Tobacco Product Applications (PMTA) for Electronic Nicotine Delivery Systems (ENDS), which recommends inclusion of in vitro toxicology ...
  2. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 32

    Cellular transformation activity of different tobacco condensates in the Bhas 42 cell assay

    STEVENSON M.(1); WIECZOREK R.(2); SIMMS L.(1); PANT K.(3)
    (1) Imperial Tobacco Limited, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    Carcinogenesis has been described as a multi-stage process comprising of initiation, promotion and progression. Smoking is a cause of serious disease in smokers, including lung cancer. Determining the carcinogenic potential of a tobacco product ingredient ...
  3. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 35

    Comparison of the carcinogenic potential of tobacco smoke and electronic-cigarette aerosol using the Bhas cell transformation assay

    BREHENY D.(1); OKE O.(1); PANT K.(2); BRUCE S.W.(2); LAFORCE M.K.(2); CELESTIN N.(2); GAÇA M.D.(1)
    (1) British American Tobacco, R&D Centre, Southampton, U.K.; (2) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    In vitro cell transformation assays (CTA) are used to assess the carcinogenic potential of chemicals and complex mixtures. They can detect non-genotoxic as well as genotoxic carcinogens. The Bhas 42 CTA has been developed with both initiation and ...
  4. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 44

    Investigation of pyrolysis behaviour of lutein in air by thermo gravimetry-single drop micro extraction-gas chromatography-mass spectrometry

    YANG Ji; YANG Liu; WU Yiqin; MIAO Mingming; ZHE Wei; CHEN Yongkuan
    China Tobacco Yunnan Industrial Co., Ltd of CNTC, R&D Center, Kunming, P.R. China
    To investigate the pyrolysis behaviour of lutein in air, an automatic single drop micro extraction (SDME) device for trapping the released fractions was designed and coupled with thermo gravimetry-gas chromatography-mass spectrometry. According to the ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2011, Graz, STPOST 06

    Evaluation of cigarette smoke-induced cell transformation using three in vitro cell transformation assays

    FOWLER K.; FIELDS W.R.; NORDSKOG B.K.; POTTS R.; BOMBICK B.R.; PANT K.
    (1) R.J. Reynolds Tobacco Co., R&D, Winston-Salem, NC, USA; (2) BioReliance Corporation, Rockville, MD, USA
    Cell transformation assays (CTA) detect phenotypic changes associated with neoplastic transformation and available evidence suggests in vitro cell transformation may stimulate early components of the multistage process of carcinogenesis. Moreover, CTAs ...
  6. TSRC, Tob. Sci. Res. Conf., 2011, 65, abstr. 22

    Cell transformation activity of cigarette smoke condensate in Bhas 42 ASSAY.

    PANT K.(1); BRUCE S.W.(1); GAIROLA C.G.(2)
    (1) BioReliance Corp Rockville, MD, USA; (2) University of Kentucky Medical Center, Lexington, KY, USA
    Cell transformation assays have been commonly used to predict chemical carcinogenicity. Using v-Ha-ras transfected BALB/c3T3 (Bhas 42) cells, Sasaki and coworkers (2010, 2011) have recently validated a sensitive short-term assay that simulates the two ...
  7. Tobacco Science & Technology, 2011, 7, p. 60-63., ISSN.1002-0861

    Transfer behavior of some carbonyl flavors in filter and tobacco rod of cigarette

    ZHANG JIE(1); ZONG YONG-LI(1); ZHOU HUI-SHUN(2); PENG SHU-HAI(1); SONG YU-BING(1)
    1. Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450001, P.R. China; 2. Technology Center of China Tobacco Jiangxi Industrial Corporation, Nanchang 330096, P.R. China
    Twelve carbonyl flavor samples were added into cut tobacco and filter tips of cigarettes and then analyzed by simultaneous distillation and extraction coupled with GC and GC/MS to determine the ratios of flavor retained in tobacco rod or filter, migrated ...
  8. Tobacco Science & Technology, 2010, 8, p. 41-45., ISSN.1002-0861

    Effects of filter length and ventilation on transfer behavior of some ester flavors in cigarette

    ZHOU HUI-SHUN(1); ZONG YONG-LI(2); ZHANG JIE(2); PENG SHU-HAI(2); SONG YU-BING(2)
    1. Technology Center, P.R. China Tobacco Jiangxi Industrial Corporation, Nanchang 330096, P.R. China; 2. Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450001, P.R. China
    In order to investigate the effects of filter length and ventilation on the transfer behavior of some ester flavors in cigarettes, the said ester flavors were injected into cigarettes with filters of various length and ventilation rates. These flavored ...
  9. CORESTA Congress, Kyoto, 2004, APOST 04

    A new Romanian flue-cured cultivar : Virginia 177

    CIUPERCA A.; PAUNESCU M.; PAUNESCU A.D.; BOLD I.; DUMITRASCU P.
    Central Research Station for Tobacco Culture and Industrialization, Bucharest, Romania.
    The improvement of the chemical and industrial quality of Virginia tobacco in Romania represents the main objective for those involved in tobacco research, production and industrialization. The most important way to achieve this objective is the change of ...