Search Results

67 results

  1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 33

    Accurate and reproducible dispensing of patterned picoliter quantities of tobacco extract onto apical surfaces of human 3D reconstructed airway tissues

    BEHRSING H.(1); SADOWSKI N.(1); CONSTANT S.(2); HUANG S.(2); RAABE H.(1)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) Epithelix Sàrl, Geneva, Switzerland
    There is an increasing need for researchers to understand the dynamic aspects of inhaled tobacco product exposure. Exposure-induced events can cause respiratory irritation, sensitisation, and other events that may lead to severe pulmonary disease. ...
  2. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 109

    3d reconstructed human airway models: effect of acclimation conditions on biomarker and inflammatory response following tissue challenge

    BEHRSING H.; RAABE H.A.; SHEEHAN D.W.; SLY E.A.; CURREN R.D.
    Institute for In Vitro Sciences, Gaithersburg, MD USA
    Human reconstructed, 3-dimensional (3D) airway tissues present researchers with organotypic models that consist of heterogenous cell types that more accurately reflect the pulmonary airway in vivo. These in vitro models are now increasingly applied to ...
  3. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 51

    Investigate particle size distributions of electronic cigarette aerosols using a multi-angle light scattering instrument

    SONG C.(1); HOLVE D.(2); ALDERMAN S.L.(1)
    (1) R.J. Reynolds Tobacco Company, Winston Salem, NC USA; (2) EnviroMetrix Instruments LLC, Berkeley, CA USA
    Particle size distribution measurement of electronic cigarette aerosols represents a great experimental challenge due to the volatile nature of the particulate compositions and the high number density (up to 1010 per cubic centimeter). Efforts have been ...
  4. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 15

    Evaluation of the EpiOral™ reconstructed human oral buccal tissue model as a testing platform for determining the oral irritation potential of tobacco products

    RAABE H.; BARNES N.; HILBERER A.
    Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.
    There is an increasing need by the tobacco industry to evaluate the oral/buccal irritation potential of tobacco products both to support product development goals and for sound product stewardship. The use of in vitro human cell and tissue-based test ...
  5. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 17

    Global profiling of metabolites from saliva of tobacco consumers

    PRASAD G.L.(1); JONES B.A.(1); SCHMIDT E.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.; (2) Metabolon, Durham, NC, U.S.A.
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term health ...
  6. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 05

    The use of precision-cut lung slices to assess inflammation, parenchymal damage, and collagen deposition: three markers of tobacco exposure-induced pulmonary toxicity

    BEHRSING H.P.
    Institute for In Vitro Sciences, Inc., Gaithersburg, Maryland, USA
    The Family Smoking Prevention and Tobacco Control Act (TCA) gives the Food and Drug Administration (FDA) broad authority to regulate tobacco products. The FDA-Center for Tobacco Products (CTP) calls for several research priority areas, including in vitro ...
  7. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 17

    Global profiling of metabolites from saliva of tobacco consumers

    PRASAD G.L.(1); JONES B.A.(1); SCHMIDT E.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA; (2) Metabolon, Durham, North Carolina, USA
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term health ...
  8. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 38

    Analysis of free amino acids in tobacco with a new LC/MS/MS procedure

    MOLDOVENAU S.C.(1); ZHU J.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA; (2) Lancaster Labs. Inc., Winston-Salem, North Carolina, USA
    The levels of amino acids in tobacco are important for leaf characterization. They contribute substantially to the level of toxicants in cigarette smoke, and to the sensory properties of cigarettes. The analysis of amino acids in tobacco leaf has been ...
  9. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPT 24

    Development of biomarkers of effect from chronic tobacco usage. Part 3: Potential metabolomics biomarkers of tobacco effect

    PRASAD G.L.(1); CHEN P.(1); JONES B.A.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA; (2) Metabolon, Durham, NC, USA
    Epidemiological data indicate that consumption of moist snuff is associated with reduced harm relative to cigarette smoking. However, a need exists for interim biomarkers of effect (BioEff) that would be useful to assess the health effects of tobacco. To ...
  10. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPTPOST 36

    Development of biomarkers of effect from chronic tobacco usage.Part 4: Metabolomic profiles from cigarette smokers and moist snuff consumers

    PRASAD G.L.(1); CHEN P.(1); JONES B.A.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA; (2) Metabolon, Durham, NC, USA
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term effects of ...