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68 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 53

    Non-targeted screening of extractables and leachables in e-cigarettes using a Single Platform UPLC-APGC-QTOF-MS

    MERUVA N.(1); CABOVSKA B.(1); SHAH D.(1); ORGANTINI K.(1); McCALL E.(2); CLELAND G.(1); ROZENICH R.(3); SCHREINER H.(3)
    (1) Waters Corporation, Milford, MA, U.S.A.; (2) Waters Corporation, Wilmslow, U.K.; (3) Waters GmbH, Vienna, Austria
    Characterization of extractables and leachables is essential for ensuring the safety, quality and efficacy of inhalation tobacco products such as e-cigarettes. The initial step for characterizing extractables from e-cigarettes involves targeted screening, ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 54

    Ion mobility mass spectrometry: a new tool for characterization of complex tobacco products

    MULLIN L.(1); MERUVA N.(1); McCALL E.(2); CLELAND G.(1); ROZENICH R.(3); SCHREINER H.(3)
    (1) Waters Corporation, Milford, MA, U.S.A.; (2) Waters Corporation, Wilmslow, U.K.; (3) Waters GmbH, Vienna, Austria
    Comprehensive chemical profiling and identification of compounds in tobacco and tobacco smoke matrices is a challenging task due to the sample complexity and the wide array of analyses required. LC-MS and GC-MS based methods are typically applied as they ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 55

    Rapid authentication of tobacco flavors using DART-MS

    ORGANTINI K.(1); MERUVA N.(1); McCALL E.(2); CLELAND G.(1); ROZENICH R.(3); SCHREINER H.(3)
    (1) Waters Corporation, Milford, MA, U.S.A.; (2) Waters Corporation, Wilmslow, U.K.; (3) Waters GmbH, Vienna, Austria
    Characterization of flavors in tobacco products is critical for consumer’s perception of aroma, taste, quality and branding. Maintaining consistent flavor in tobacco products requires quality control testing of raw materials and finished products to ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 56

    Benefits of mass detection for routine LC analysis of tobacco products

    MERUVA N.(1); YANG J.(1); McCALL E.(2); ROZENICH R.(3); SCHREINER H.(3)
    (1) Waters Corporation, Milford, MA, U.S.A.; (2) Waters Corporation, Wilmslow, U.K.; (3) Waters GmbH, Vienna, Austria
    There are several tobacco industry methods that rely on HPLC separation and optical detection (UV, Fluorescence and ELSD) for identification of target compounds such as carbonyls, nicotine, related alkaloids, sugars and artificial sweeteners. In this ...
  5. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 51

    Investigate particle size distributions of electronic cigarette aerosols using a multi-angle light scattering instrument

    SONG C.(1); HOLVE D.(2); ALDERMAN S.L.(1)
    (1) R.J. Reynolds Tobacco Company, Winston Salem, NC USA; (2) EnviroMetrix Instruments LLC, Berkeley, CA USA
    Particle size distribution measurement of electronic cigarette aerosols represents a great experimental challenge due to the volatile nature of the particulate compositions and the high number density (up to 1010 per cubic centimeter). Efforts have been ...
  6. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 17

    Global profiling of metabolites from saliva of tobacco consumers

    PRASAD G.L.(1); JONES B.A.(1); SCHMIDT E.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.; (2) Metabolon, Durham, NC, U.S.A.
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term health ...
  7. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 17

    Global profiling of metabolites from saliva of tobacco consumers

    PRASAD G.L.(1); JONES B.A.(1); SCHMIDT E.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA; (2) Metabolon, Durham, North Carolina, USA
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term health ...
  8. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 38

    Analysis of free amino acids in tobacco with a new LC/MS/MS procedure

    MOLDOVENAU S.C.(1); ZHU J.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA; (2) Lancaster Labs. Inc., Winston-Salem, North Carolina, USA
    The levels of amino acids in tobacco are important for leaf characterization. They contribute substantially to the level of toxicants in cigarette smoke, and to the sensory properties of cigarettes. The analysis of amino acids in tobacco leaf has been ...
  9. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPT 24

    Development of biomarkers of effect from chronic tobacco usage. Part 3: Potential metabolomics biomarkers of tobacco effect

    PRASAD G.L.(1); CHEN P.(1); JONES B.A.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA; (2) Metabolon, Durham, NC, USA
    Epidemiological data indicate that consumption of moist snuff is associated with reduced harm relative to cigarette smoking. However, a need exists for interim biomarkers of effect (BioEff) that would be useful to assess the health effects of tobacco. To ...
  10. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPTPOST 36

    Development of biomarkers of effect from chronic tobacco usage.Part 4: Metabolomic profiles from cigarette smokers and moist snuff consumers

    PRASAD G.L.(1); CHEN P.(1); JONES B.A.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA; (2) Metabolon, Durham, NC, USA
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term effects of ...