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80 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 62

    Immune functions are perturbed to a greater extent with smoking rather than moist snuff use

    TRAN Q.T.(1); ARIMILLI S.(2); JOHNSON E.(3); LIU Gang(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Wake Forest University, School of Medicine, Department of Microbiology and Immunology, Winston-Salem, NC, U.S.A.; (3) University of North Carolina, Department of Mathematics and Statistics, Greensboro, NC, U.S.A.
    Cigarette smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (CVD). Existing epidemiological data suggest moist snuff consumption is generally associated with reduced health risks...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 066

    Distinct gene expression changes in peripheral blood mononuclear cells exposed to combustible versus non-combustible tobacco product preparations

    TRAN N.Q.(1); ARIMILLI S.(2); MADAHIAN B.(3); HOMAYOUNI R.(3); PRASAD G.L.(1)
    (1) RAI Services, Winston-Salem, NC, USA; (2) Wake Forest University, Winston-Salem, NC, USA; (3) Quire Inc., Memphis, TN, USA
    Cigarette smoking exerts diverse physiological effects including immune suppression. Existing epidemiological data show that consumption of smokeless tobacco products, such as moist snuff, is less harmful relative to smoking. We previously...
  3. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 080

    Differential gene expression and functional responses in peripheral blood mononuclear cells pretreated with combustible and non-combustible tobacco products

    TRAN Q.T.(1); ARIMILLI S.(2); LIU Gang(1); MAKENA P.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Wake Forest School of Medicine, Winston-Salem, NC, USA
    Chronic smoking is known to alter immune responses, which compromises tumor surveillance and host defense against microbial infections. We previously showed that smokers (SMK) exhibit distinct peripheral blood mononuclear cell (PBMC) gene expression...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 19

    Combustible and smokeless tobacco product preparations differentially regulate calcium mobilization in the human leukemic HL60 cell line

    MAKENA P.(2); ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Wake Forest University School of Medicine, Department of Microbiology & Immunology, Winston-Salem, NC, U.S.A.; (2) RAI Services Co., Winston-Salem, NC 27102, U.S.A.
    Increased calcium (Ca2+) mobilization is central to leukocyte signaling and for regulation of immune responses. Although evidence suggests that cigarette smoking affects several biological functions including inflammatory responses, how the use of...
  5. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 40

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2)
    (1) Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, U.S.A.; (2) Department of Microbiology & Immunology, Wake Forest University Health Sciences, U.S.A.
    Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and...
  6. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 17

    Ex vivo effects of smokeless tobacco extracts on select immune responses

    PRASAD G.L.(1); ARIMILLI S.(2); DAMRATOSKI B.E.(2); SCHMIDT E.(1); ROWE J.(3); CHOUCHANE S.(4)
    (1) RAI Services Company; (2) Wake Forest University Health Sciences; (3) R.J. Reynolds Tobacco Co.; (4) Eurofins Lancaster Labs Inc, Winston-Salem, NC, USA
    Our previous work demonstrated that exposure to Tobacco Product Preparations (TPPs) from combustible tobacco cause cytotoxic and select immunosuppressive effects in PBMCs, and this ex vivo model is well suited to investigate the chronic immune...
  7. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 51

    Investigate particle size distributions of electronic cigarette aerosols using a multi-angle light scattering instrument

    SONG C.(1); HOLVE D.(2); ALDERMAN S.L.(1)
    (1) R.J. Reynolds Tobacco Company, Winston Salem, NC USA; (2) EnviroMetrix Instruments LLC, Berkeley, CA USA
    Particle size distribution measurement of electronic cigarette aerosols represents a great experimental challenge due to the volatile nature of the particulate compositions and the high number density (up to 1010 per cubic centimeter). Efforts have...
  8. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 38

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Department of Microbiology & Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, U.S.A.; (2) R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking is known to adversely impact innate and adaptive immune responses, resulting in immunosuppression, which has been linked to increased susceptibility of smokers to microbial infections and higher incidences of cancer relative...
  9. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 17

    Global profiling of metabolites from saliva of tobacco consumers

    PRASAD G.L.(1); JONES B.A.(1); SCHMIDT E.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.; (2) Metabolon, Durham, NC, U.S.A.
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term health...
  10. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 17

    Global profiling of metabolites from saliva of tobacco consumers

    PRASAD G.L.(1); JONES B.A.(1); SCHMIDT E.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA; (2) Metabolon, Durham, North Carolina, USA
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term health...