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40 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 43

    In vitro micronucleus (MN) assay using TK6 cells: review of historical positive and negative control data

    STANKOWSKI L.F. Jr(1); HURTADO S.B.(1); WELLS M.M.(1); KWOK V.Y.(1); DOSHI U.(2); COFFA B.G.(2); LEE K.M.(2)
    (1) Charles River Laboratories, Genetic and In Vitro Toxicology, Skokie, IL, U.S.A.; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond, VA, U.S.A.
    TK6 human lymphoblastoid cells are widely used in the in vitro MN assay as a part of regulatory genotoxicity testing for pharmaceuticals, but have seen relatively limited use in testing of other test materials, including tobacco-related products. As an ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 46

    Validation of an in vitro test battery to evaluate smokeless tobacco products

    HURTADO S.B.(1); LALLIER B.(1); TYDRICK C.(1); LIU Z.(2); GUMP J.(2); BISWAS K.(2); KWOK V.Y.(1); STANKOWSKI L.F. Jr(1)
    (1) Charles River Laboratories, Genetic and In Vitro Toxicology, Skokie, IL, U.S.A.; (2) Charles River Laboratories, Analytical Chemistry, Ashland, OH, U.S.A.
    Evaluating potential cytotoxicity and genotoxicity of smokeless tobacco products poses unique challenges for in vitro testing. Each product is a complex mixture of vegetable matter, and may include a packaging component as part of the final product. ...
  3. CORESTA Congress, Paris, 2006, PT 20

    Feature selection from near infrared spectra using genetic algorithms for tobacco blend recognition

    FIGUERES G.; DE SOUZA S.; REYNES C.; SABATIER R.; VIDAL B.
    Altadis Research Centre, Fleury-les-Aubrais, France
    Near infrared reflectance spectroscopy has proved to be very useful for predicting concentrations of chemical compounds in tobacco, classification or pattern recognition of cigarette blends. The resulting measurement of a sample is a whole reflectance ...
  4. CORESTA Congress, Paris, 2006, SS 01

    How representative of the human smoking behaviour would be the new alternative smoking regimes? A first attempt of assessment

    MARCHAND V.; TESSIER C.; DUMERY B.
    Altadis Research Centre, Fleury-les-Aubrais, France
    The ISO or FTC smoking conditions (35 mL- 2 s puffs, 1 puff per minute) have been more and more criticized during the last decade, especially because they would not reflect the human smoking behaviour. Their main objective was not to predict the exact ...
  5. CORESTA Congress, Paris, 2006, SS 13

    A mixture experimental design with six variables and the effects on smoke components:1 - Presentation of this experimental design and of some initial results on physical characteristics of cigarettes and blends

    VIDAL B.; FIGUERES G.; BIESSE J.P.; BREGEON B.; LOUVET F.; MUZELLEC L.
    Altadis Research Centre, Fleury-les-Aubrais, France
    The objective of this paper is to examine the effects of six tobacco components on the chemical and physical characteristics of blends and cigarettes and particularly on the mainstream smoke yields. First of all, we will develop the philosophy of this ...
  6. CORESTA Congress, Paris, 2006, SS 14

    A mixture experimental design with 6 variables and the effects on smoke components:2 - Hoffmann analytes behaviour through a mixture experimental design

    FIGUERES G.; VIDAL B.; BIESSE J.P.; BREGEON B.; LOUVET F.; MUZELLEC L.
    Altadis Research Centre, Fleury-les-Aubrais, France
    Today in the tobacco industry, one of the main scientific challenges is to understand the formation of some smoke compounds ("Hoffmann analytes"). For several years, work has been conducted in order to know the influence of cigarette design ...