Search Results

59 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 12

    Review of current methodologies in evaluating abuse liability of nicotine and tobacco products in the U.S. regulatory environment

    EVANS S.(1); KONG M.C.(2); CAMPBELL L.(2); SHERWOOD N.(3); PRASAD K.(4)
    (1) Turning Point Brands, Louisville, KY, U.S.A.; (2) Altasciences Clinical Research, Laval, Canada; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) British American Tobacco, R&D, Millbrook, Southampton, U.K.
    Traditional definitions of abuse and misuse do not apply to a consumer product such as tobacco that consumers essentially use ‘as intended’. In contrast to pharmaceutical products, a guidance for abuse liability testing of nicotine and tobacco...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 52 (also presented at TSRC 2019)

    Application of differential ion mobility spectrometry-tandem mass spectrometry for improved assay selectivity and sensitivity in the quantitation of tobacco biomarkers NNN, NNAL and 2-/3-HPMA in human urine

    PLOMLEY J.B.
    Altasciences, Laval, QC, Canada
    Differential ion mobility spectrometry (DMS) has recently emerged as an orthogonal gas-phase ion separation technique which, when interfaced between liquid chromatography (LC) and tandem mass spectrometry (MS/MS), promises improvements in both assay...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 044

    Abuse liability of very low nicotine content cigarettes with characterization of nicotine exposure profiles in adult smokers

    LEVY-COOPERMAN N.(1); SHRAM M.J.(1); KELSH D.(2); VINCE B.(2); CARMINES E.(3)
    (1) Altreos Research Partners, Toronto, ON, Canada; (2) Altasciences/Vince and Associates, Overland Park, KS, USA; (3) Carmines Consulting, Scottsdale, AZ, USA
    Objectives: In 2017, FDA announced the intention to explore limiting nicotine in cigarettes to minimal/non-addictive levels. Research indicates that reduced nicotine content would potentially limit reinforcing effects of cigarettes. We conducted 2...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 102 (also presented at CORESTA SSPT2019)

    Novel application of differential ion mobility spectrometry-tandem mass spectrometry for improved assay selectivity and sensitivity in the quantitative determination of total NNN total NNAL and 2- / 3-HPMA in human urine

    PLOMLEY J.
    Altasciences, Laval, Canada
    Differential Ion Mobility Spectrometry (DMS) has recently emerged as an orthogonal gas-phase ion separation technique which, when interfaced between liquid chromatography (LC) and Tandem Mass Spectrometry (MS/MS), promises improvements in both assay...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 56

    Photoionization time-of-flight mass spectrometry as a tool for the identification of selected isomers in the gas phase of mainstream cigarette smoke

    HU Yonghua(1); WANG Jian(1); TIAN Zhenfeng(1); CHEN Kaibo(1); XU Yingbo(1); PAN Yang(2)
    (1) Technology Center, China Tobacco Anhui Industrial Co., Ltd., Hefei, Anhui, P.R. China; (2) National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, P.R. China
    To identify selected isomers in the gas phase of mainstream cigarette smoke, an on-line measurement system with a photoionization unit was built. With this instrument, photoionization efficiency (PIE) curves for constituents in the gas phase of...
  6. CORESTA Meeting, Agronomy/Phytopathology, 2015, Izmir, Turkey, APPOST 06

    Materials, energy and value flows analysis of different tobacco planting patterns in Southern Anhui area

    ZHANG Jiguang(1); ZHANG Zhongfeng(1); YAO Zhongda(2); ZHANG Fujian(2); GUO Dongfeng(2); JI Xuejun(3); ZHU Qifa(3); XUE Lin(3); SHEN Guoming(1)
    (1) Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Key Laboratory of Tobacco Biology and Processing, Ministry of Agriculture, Qingdao, P.R. China; (2) China Tobacco Anhui Industrial Co. Ltd., Hefei, P.R. China; (3) Anhui Wannan Tobacco Leaf Co. Ltd, Xuancheng, P.R. China
    The reasonable choice of tobacco planting pattern is very important to improve the efficiency of tobacco field ecosystems and to promote the sustainable development of modern tobacco agriculture. In this study, the materials, energy and value flow...
  7. Tobacco Science & Technology, 2012, 1, p. 34-42., ISSN.1002-0861

    Analysis of important aroma components in tobacco by GC-MS with selective ion mode

    HUANG Lan(1); XU Yingbo(1); TIAN Zhenfeng(1); LI Lu(1); ZHU Dongliang(1); ZHU Xiaolan(2)
    (1) Technology Center, China Tobacco Anhui Industrial Co., Ltd., Hefei 230088, P.R. China; (2) Research Center of Tobacco and Health, University of Science and Technology of China, Hefei 230052, P.R. China
    The cut tobacco in cigarette samples was prepared with optimized simultaneous distillation and extraction by using phenylethyl acetate as an internal standard (IS). The aroma components in the samples were analyzed by GC/MS with selective ion mode....
  8. Tobacco Science & Technology, 2012, 11, p. 38-41, 50, ISSN.1002-0861

    Combustion characteristics of flue-cured tobacco and its kinetic analysis

    XIA Ming(1); LI Jinguang(1); QIAO Guobao(1); JIANG Jianjun(1); HU Yonghua(2)
    (1) Chuzhou Cigarette Factory, China Tobacco Anhui Industrial Co., Ltd., Chuzhou 239000, Anhui, P.R. China; (2) Technology Center, China Tobacco Anhui Industrial Co., Ltd., Hefei 230088, P.R. China
    In order to investigate the effects of combustion conditions on the thermal behavior of flue-cured tobacco, the thermal decomposition and combustion characteristics of flue-cured tobacco at different oxygen concentrations and heating rates were...