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147 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 19

    In vitro biological impact evaluation of whole cigarette smoke by using pathway-based approach

    CHEN H.(1,2); CHEN X.(1,2); SHEN Y.(3); LIU F.(1,2); YIN X.(1); LIU L.(1); TIMKO M.(4); QI H.(5); FAN L.(1,2,3)
    (1) Institute of Crop Science, Zhejiang University, Hangzhou, P.R. China; (2) Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, P.R. China; (3) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (4) Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, U.S.A.; (5) Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, P.R. China
    Harm-reduced cigarettes have been greatly developed to minimize the negative impact of smoking on health. However, the practical effects of such products are still under debate. Along with the application of high-throughput sequencing technologies...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 27

    Next generation product aerosol bubbled extracts show little to no effect in high content screening endpoints when compared to cigarette smoke bubbled extracts

    TRELLES STICKEN E.(1); WIECZOREK R.(1); BODE L.M.(1); SIMMS L.(2); STEVENSON M.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), BioToxLab, Hamburg, Germany; (2) Imperial Tobacco Limited, In vitro Research, Bristol, U.K.
    Tobacco-based and tobacco-free next generation products (NGPs) are understood to be a less harmful alternative to conventional combustible cigarettes. The objective of this study was to compare the in vitro biological response of cigarette smoke...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 34

    Next generation product aerosols induce lower biological activity than combusted cigarettes: a comparison of in vitro cell migration in the scratch wound assay

    RUDD K.(1); BUDDE J.(2); TRELLES STICKEN E.(2); WIECZOREK R.(2); SIMMS L.(1); STEVENSON M.(1)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    Smoking combustible cigarettes is a cause of serious diseases in smokers, including heart disease. There are many commercially available next generation products (NGPs), such as tobacco-free e-vapour products, aiming to provide an alternative to...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 37

    Use of cell media nicotine concentration as a marker to predict cells surface deposited nicotine in transwells after fresh smoke/aerosol exposure

    WIECZOREK R.(1); TRELLES STICKEN E.(1); BODE L.M.(1); SIMMS l.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Imperial Tobacco Limited, Bristol, U.K.
    Exposure of organotypic 3D lung models at the air liquid interface (ALI) to fresh whole smoke/aerosol provides a more human relevant exposure assessment of combustible cigarettes and e-vapour products. The aim of this study is to present a method...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 01

    The application of in vitro Toxicity Testing in 21 Century (TT21C) for next generation products

    SIMMS L.(1); TRELLES STICKEN E.(2)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The aim is to demonstrate the feasibility of TT21C in vitro methods as part of an overall assessment framework for next generation products (NGP). TT21C methodologies can be used to assess harm reduction potential of NGPs using human-derived...
  6. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, APPOST 05

    Effect of Qianhefu water-soluble foliar fertilizer on the quality of flue-cured tobacco leaf

    XU Chunping(1); BAI Jiafeng(2); HU Zhizhong(2); JIA Ke(1); MA Kuoyan(3)
    (1) College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou, P.R. China; (2) Technical Center of China Tobacco Guangxi Industrial Co. Ltd, Nanning, Guanxi, P.R. China; (3) Technical Center of China Tobacco Chongqing Industrial Co., Ltd., Chongqing, P.R. China
    A field experiment was carried out to investigate the effect of Qianhefu water-soluble foliar fertilizer on the quality of tobacco leaf. The results showed that the foliar fertilizer played an important role in improving agronomic traits of tobacco...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 01

    In vitro biological safety evaluation of cigarette smoke

    CHEN Xi(1,2); SHEN Y.(1,2); CHEN Hongyu(1,2); LIU F.(1,2); QI H.(3); JIMIN S.(3); TIMKO M.(4); FAN L.(1,2)
    (1) Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, P.R. China; (2) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (3) Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, P.R. China; (4) Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, U.S.A.
    Traditionally, toxicological evaluation of cigarette smoke has focused on the harmful chemical content of smoke. Harm-reduced cigarettes should not only refer to these chemical compounds, but also to the degree of the effect of whole smoke on human...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 56

    Photoionization time-of-flight mass spectrometry as a tool for the identification of selected isomers in the gas phase of mainstream cigarette smoke

    HU Yonghua(1); WANG Jian(1); TIAN Zhenfeng(1); CHEN Kaibo(1); XU Yingbo(1); PAN Yang(2)
    (1) Technology Center, China Tobacco Anhui Industrial Co., Ltd., Hefei, Anhui, P.R. China; (2) National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, P.R. China
    To identify selected isomers in the gas phase of mainstream cigarette smoke, an on-line measurement system with a photoionization unit was built. With this instrument, photoionization efficiency (PIE) curves for constituents in the gas phase of...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 08

    Effects of treatment time of ultraviolet irradiation and ozone on the internal quality of the redrying tobacco

    XU Chunping(1); BAI Jiafeng(2); ZHENG Kai(3); ZHU Guocheng(3); HU Zhizhong(2); JIANG Yu(1); XU Heng(4); LI Shufang(3); YANG Zhiqiang(3)
    (1) College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou, Henan, P.R. China; (2) Technical Center, China Tobacco Guangxi Industrial Co. Ltd, Nanning, Guanxi, P.R. China; (3) Xuchang Cigarette Factory, China Tobacco Henan Industrial Co., Ltd., Xuchang, Henan, P.R. China; (4) Technical Center, China Tobacco Henan Industrial Co., Ltd, Zhengzhou, Henan, P.R. China
    To investigate the effect of ultraviolet (UV) radiation and ozone on the internal quality of redrying tobacco, Qujing redrying tobacco (B2F) was selected as experimental material and irradiated by UV irradiation (producing ozone) and treated with...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 10

    Principal component analysis of volatile components in refill liquids for electronic cigarettes with different tastes

    XU Chunping(1); MA Kuoyan(2); HAO Hui(3); CHEN Zhifei(3); ZHAO Shanshan(1)
    (1) College of Food and Biology Engineering, Zhengzhou University of Light Industry, Zhengzhou, P.R. China; (2) Technical Center of China Tobacco Chongqing Industrial Co., Ltd., Chongqing, P.R. China; (3) Technical Center of China Tobacco Henan Industrial Co. Ltd, Zhengzhou, Henan, P.R. China
    In this study the characterization of refill liquids for different electronic cigarettes with different tastes was compared. GC/MS and principal component analysis were employed to analyze the volatile components in refill liquids for five kinds of...