Search Results

61 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 42

    Characterization of whole mainstream smoke/aerosol delivery within the Vitrocell® Ames 48 high throughput exposure module using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); SEYMOUR A.(2); HOLLINGS M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, U.K.
    The preferred means of assessing combustible or other aerosol-generating tobacco products in vitro is by direct exposure of cell cultures to freshly generated whole mainstream smoke/aerosols. This approach eliminates the fractionation of...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 49

    The CORESTA in vitro test battery for combustible tobacco products: update from the 2004 Rationale and Strategy Report

    LEE K.M.(1); JORDAN K.G.(2); WIECZOREK R.(3); MOENNIKES O.(4); CLEMENTS J.(5); CROOKS I.(6); HASHIZUME T.(7); MILLER J.(8); WEBER E.(9); YOSHINO K.(7)
    (1) Altria Client Services, Richmond, VA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.; (3) Imperial Brands, Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (4) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (5) Covance Laboratories Ltd, Harrogate, U.K.; (6) British American Tobacco (Investments) Ltd, R&D, Southampton, U.K.; (7) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (8) JT International SA, Geneva, Switzerland; (9) Ökolab, Vienna, Austria
    In 2004, the CORESTA In Vitro Toxicity Task Force issued a rationale and strategy report, commonly known as “the CORESTA in vitro test battery guideline”. The goals of this guideline were to: 1) develop the rationale and strategy for conducting in...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 50 (also presented at TSRC 2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, U.S.A.
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and chronic obstructive pulmonary disease (COPD). One of the key functions of lung epithelial cells is to serve as a physical barrier against insults...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 51

    Structural investigation of the tobacco specific urinary biomarker iPX

    SCHMIDT E.; PRASAD G.L.
    RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.
    Biomarkers of potential harm (BoPH) are tools to assess biological and pathophysiological effects associated with chronic tobacco product use, such as oxidative stress. Isoprostanes are widely recognized as BoPH for assessing endogenous oxidative...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 52 (also presented at TSRC 2019)

    A blood-based smoking-related gene expression signature using a machine learning approach

    LIU G.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Smoking is a leading risk factor in the onset of multiple forms of cancer, chronic obstructive pulmonary disease, and cardiovascular disease. At present, there is a limited understanding by which changes in gene expression profiles in blood or other...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 58

    A consortium approach for consumer-reported outcome measures to assess tobacco- and nicotine-containing products

    ACQUADRO C.(1) on behalf of the CORESTA CROM Task Force: AYALA-FIERRO F.(2); BLACK R.(3); CAHOURS X.(4); CHREA C.(5); CURTIN G.(6); GILES L.(7); McCAFFREY S.(3); PARK C.H.(8); PRASAD K.(9); SHERWOOD N.(10); SHIFFMAN S.(11); SMITH J.(6); SPIES E.(5)
    (1) Mapi Research Trust, Lyon, France; (2) ITG Brands, Greensboro, NC, U.S.A.; (3) Altria Client Services, Richmond, VA, U.S.A.; (4) SEITA - Imperial Brands, Paris, France; (5) Philip Morris Products S.A., Neûchatel, Switzerland; (6) RAIS, Winston-Salem, NC, U.S.A.; (7) JT Int'l SA, Genève, Switzerland; (8) KT&G Research Institute, Daejeon, Republic of Korea; (9) British American Tobacco, Southampton, U.K.; (10) Neil Sherwood Consulting, Commugny, Switzerland; (11) Pinney Associates, Pittsburgh, PA, U.S.A.
    In the tobacco space, consumer-reported outcome measures (CROM) are essential for understanding motivations, subjective effects, and behavior. Such measures have become particularly important with the advent of candidate modified risk tobacco...
  7. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 015

    Levels of endothelial progenitor cells (EPCs) in smokers and moist snuff consumers

    ARIMILLI S.(1); CHEN P.(2); PRASAD G.L.(2)
    (1) Eurofins Professional Scientific Services, Winston Salem, NC, USA; (2) RAI Services Company, Winston Salem, NC, USA
    Endothelial progenitor cells (EPCs) are a key cell type present in circulation and are reported to play a role in the development of cardiovascular diseases. EPCs are derived from the bone marrow and mediate the differentiation, regeneration and...
  8. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 016

    Beliefs, perceptions, and behavioral intentions related to nicotine, low nicotine cigarettes, and reduced risk products among U.S. adults

    PARMS T.; FROST-PINEDA K.
    RAI Services Company, Winston-Salem, NC, USA
    In March 2018, the U.S. Food and Drug Administration (FDA) published an advance notice of proposed rulemaking to obtain information for consideration in developing a tobacco product standard to set the maximum nicotine level for cigarettes. We...
  9. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 017

    Beliefs and perceptions about nicotine and “minimally addictive” cigarettes among adult current, former, and never smokers

    PARMS T.; FROST-PINEDA K.; CURTIN G.
    RAI Services Company, Winston-Salem, NC, USA
    In March 2018, the US Food and Drug Administration (FDA) issued an advance notice of proposed rulemaking (ANPRM) seeking information on a tobacco product standard potentially lowering nicotine levels in combustible cigarettes. Understanding consumer...
  10. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 019

    Simulated leachables assessment for critical components used in cartridges of electronic nicotine delivery systems

    CULBERT C.(1); WEIDMAN R.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    Electronic Nicotine Delivery Systems (ENDS) contain e-liquid formulations that are heated to generate aerosols. The potential for chemicals to leach from the device materials into the e-liquid and transfer into the aerosol has been an area of...