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146 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 12

    Determination of nicotine in gas vapour phase in phosphate buffered saline by UHPLC-MS/MS

    HOLLINGS M.(1); THOMPSON N.(2); LARNER J.(1); CLEMENTS J.(1)
    (1) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.; (2) Broughton Nicotine Services, Earby, Lancashire, U.K.
    A liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed to quantify nicotine in gas vapour phase (GVP) collected in calcium and magnesium free phosphate buffered saline (CMF-PBS). In this method the aerosol was trapped in ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 42

    Characterization of whole mainstream smoke/aerosol delivery within the Vitrocell® Ames 48 high throughput exposure module using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); SEYMOUR A.(2); HOLLINGS M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, U.K.
    The preferred means of assessing combustible or other aerosol-generating tobacco products in vitro is by direct exposure of cell cultures to freshly generated whole mainstream smoke/aerosols. This approach eliminates the fractionation of smoke/aerosols ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 43

    Dosimetric analysis of aerosol generated by a Vitrocell® VC10® Smoking Robot – investigations on dose dependency and consistency of application

    SEYMOUR A.; HOLLINGS M.; LARNER J.; CLEMENTS J.
    Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    Quartz Crystal Microbalances were used to assess the suitability of the Vitrocell ® VC10 ® exposure system. The main objective of the study was to deliver smoke aerosol in a consistent and dose dependent manner across a range of module formats. Dose ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 49

    The CORESTA in vitro test battery for combustible tobacco products: update from the 2004 Rationale and Strategy Report

    LEE K.M.(1); JORDAN K.G.(2); WIECZOREK R.(3); MOENNIKES O.(4); CLEMENTS J.(5); CROOKS I.(6); HASHIZUME T.(7); MILLER J.(8); WEBER E.(9); YOSHINO K.(7)
    (1) Altria Client Services, Richmond, VA, U.S.A.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.; (3) Imperial Brands, Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (4) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (5) Covance Laboratories Ltd, Harrogate, U.K.; (6) British American Tobacco (Investments) Ltd, R&D, Southampton, U.K.; (7) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (8) JT International SA, Geneva, Switzerland; (9) Ökolab, Vienna, Austria
    In 2004, the CORESTA In Vitro Toxicity Task Force issued a rationale and strategy report, commonly known as “the CORESTA in vitro test battery guideline”. The goals of this guideline were to: 1) develop the rationale and strategy for conducting in vitro ...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 049

    High throughput air liquid interface exposure modules: characterization of smoke/aerosol dosimetry and in vitro mutagenicity and cytotoxicity of two tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); HOLLINGS M.(2); SEYMOUR A.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Covance Laboratories, North Yorkshire, UK
    The utilization of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessments of freshly generated whole smoke/aerosol from combustible cigarettes and tobacco heating products (THPs), as well as electronic nicotine delivery ...
  6. 48th TWC, Tob. Work. Conf., 2018, abstr. 41

    Search for varieties with useful resistance to Black Shank under Georgia growing conditions

    SHEALEY J.(1); DAWSON J.(1); TAYLOR J.(1); BEASLEY E.(1); BARNES T.(1); ANDERSON H.H.(1); VON WALDNER D.M.(1); MOORE J.M.(1); BERTRAND P.F.(1); LEWIS R.S.(2)
    (1) University of Georgia, Statenville GA USA; (2) North Carolina State University, Raleigh NC USA
    As new varieties of black shank resistant tobacco are brought to the market extension agents in Georgia annually conduct variety trials across the state to measure performance and Florida 301 resistance levels throughout our tobacco producing region. It ...
  7. 48th TWC, Tob. Work. Conf., 2018, abstr. 45

    Evaluation of fungicides for control of Black Shank in tobacco

    HOLLIFIELD S.(1); SHEALEY J.(1); BERTRAND P.F.(1); MOORE J.M.(1); DOWDY M.H.(1); SHEW H.D.(2)
    (1) University of Georgia, Quitman GA USA; (2) North Carolina State University, Raleigh NC USA
      Reference only. Abstract submission was on a voluntary basis. 2018-1-2047 HOLLIFIELD S. SHEALEY J. BERTRAND P.F. MOORE J.M. DOWDY M.H. SHEW H.D. English University of Georgia NCSU 48th TWC, Tob. Work. Conf., 2018, abstr. 45 Tobacco Workers Conference ...