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48 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 049

    Assessment of in vitro toxicity/genotoxicity of ends and combustible products

    JORDAN K.(1); BOMBICK B.(1); COOPER B.(1); LEVERETTE R.(1); SHUTSKY T.(1); WEST C.(1); STRASSER J.(1); ROUND E.(1); MARANO K.M.(1); MOMIN R.(2); TRIVEDI A.(2); WAGSTAFF W.(2); BRUCE S.(3); DAKOULAS E.(3); ROY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labstat International ULC, Kitchener, ON, Canada; (3) BioReliance Corp, Rockville, MD, USA
    In May 2016, the U.S. Food and Drug Administration Center for Tobacco Products (CTP) issued draft guidance for Premarket Tobacco Product Applications (PMTA) for Electronic Nicotine Delivery Systems (ENDS), which recommends inclusion of in vitro...
  2. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 32

    Cellular transformation activity of different tobacco condensates in the Bhas 42 cell assay

    STEVENSON M.(1); WIECZOREK R.(2); SIMMS L.(1); PANT K.(3)
    (1) Imperial Tobacco Limited, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    Carcinogenesis has been described as a multi-stage process comprising of initiation, promotion and progression. Smoking is a cause of serious disease in smokers, including lung cancer. Determining the carcinogenic potential of a tobacco product...
  3. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 35

    Comparison of the carcinogenic potential of tobacco smoke and electronic-cigarette aerosol using the Bhas cell transformation assay

    BREHENY D.(1); OKE O.(1); PANT K.(2); BRUCE S.W.(2); LAFORCE M.K.(2); CELESTIN N.(2); GAÇA M.D.(1)
    (1) British American Tobacco, R&D Centre, Southampton, U.K.; (2) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    In vitro cell transformation assays (CTA) are used to assess the carcinogenic potential of chemicals and complex mixtures. They can detect non-genotoxic as well as genotoxic carcinogens. The Bhas 42 CTA has been developed with both initiation and...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2011, Graz, STPOST 06

    Evaluation of cigarette smoke-induced cell transformation using three in vitro cell transformation assays

    FOWLER K.; FIELDS W.R.; NORDSKOG B.K.; POTTS R.; BOMBICK B.R.; PANT K.
    (1) R.J. Reynolds Tobacco Co., R&D, Winston-Salem, NC, USA; (2) BioReliance Corporation, Rockville, MD, USA
    Cell transformation assays (CTA) detect phenotypic changes associated with neoplastic transformation and available evidence suggests in vitro cell transformation may stimulate early components of the multistage process of carcinogenesis. Moreover,...
  5. TSRC, Tob. Sci. Res. Conf., 2011, 65, abstr. 22

    Cell transformation activity of cigarette smoke condensate in Bhas 42 ASSAY.

    PANT K.(1); BRUCE S.W.(1); GAIROLA C.G.(2)
    (1) BioReliance Corp Rockville, MD, USA; (2) University of Kentucky Medical Center, Lexington, KY, USA
    Cell transformation assays have been commonly used to predict chemical carcinogenicity. Using v-Ha-ras transfected BALB/c3T3 (Bhas 42) cells, Sasaki and coworkers (2010, 2011) have recently validated a sensitive short-term assay that simulates the...
  6. CORESTA Congress, Kyoto, 2004, A 02

    Decision support system for soil fertility and water quality - evaluation in FCV tobacco- growing zones of India

    KRISHNAMURTHY V.; RAVISANKAR H.; DEO SINGH K.
    Central Tobacco Research Institute (CTRI), Rajahmundry (A.P.) India
    Information Technology has become an integral part of our day-to-day life. In agriculture, computers are extensively used to disseminate the information on soils, water, climatic conditions, pest and disease management and one such information system...
  7. Bull. Spec. CORESTA Congress, Lisbon, 2000, p. 140, PPOST8

    Bio-intensive integrated management of budworm, Helicoverpa armigera in FCV tobacco

    SITARAMAIAH S.; GUNNESWARA RAO S.; RAMAPRASAD G.; SREEDHAR U.
    Central Tobacco Research Institute (CTRI), Rajahmundry (A.P.) India
    Tobacco budworm, Helicoverpa armigera , is one of the limiting factors in successful production of Flue Cured Virginia (FCV) tobacco in Andhra Pradesh, India. It infests the crop during the grand growth period and inflicts severe damage to the bud...