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29 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 19 (also presented at TSRC 2018)

    Characterization of a temperature regulated e-cigarette for potential use as a reference device

    GILLMAN I.G.; PENNINGTON A.
    Enthalpy Analytical, Inc., Durham, NC, U.S.A.
    The development and adoption of a well characterized reference e cigarette would be useful during the routine analysis of e cigarette emissions. One possible class of devices that might be suitable for use as a reference e cigarette are temperature ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 32

    Characterization and in vitro testing of whole smoke condensates from combustible cigarettes

    DOSHI U.(1); GARDNER W.P.(1); GILLMAN I.G.(2); LEE K.M.(1)
    (1) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond, VA, U.S.A.; (2) Enthalpy Analytical, Inc., Richmond, VA, U.S.A.
    Health Canada recommends in vitro testing of separately collected gas and particulate phases of cigarette smoke for cytotoxicity and genotoxicity assessment. While these test materials have shown cytotoxicity and genotoxicity in literature, there has been ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 34

    Characterization of an air-liquid-interface (ALI) in vitro exposure system (VITROCELL® VC1/7 and Ames 48) using a prototype e-vapor product

    ZHANG Jingjie(1); DOSHI U.(1); OLDHAM M.J.(1); COFFA B.G.(1); GILLMAN I.G.(2); WOLZ R.L.(2); KOSACHEVSHY P.(2); LEE K.M.(1)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Enthalpy Analytical, Inc., Richmond, VA, U.S.A.
    Direct delivery of aerosol or vapor to the apical surface of cells (ALI) allows more relevant exposure for in vitro toxicological evaluation of inhalable chemicals. In this study, we quantitatively characterized the aerosol delivery in a commercially ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 45

    Ames assay cytotoxic assessment using bacterial lawn integrity with 35 mm plate spread technique

    BHARTI S.K.(1); FARISS M.W.(2); DESAI P.(1)
    (1) Enthalpy Analytical, Inc., Henrico, VA, U.S.A.; (2) ToxSynergy LLC, Midlothian, VA, U.S.A.
    Background: The Ames assay is commonly used to evaluate the mutagenic potential of tobacco products for regulatory purposes. A significant increase in the number of His+ revertant colonies observed in agar containing Salmonella bacteria and a test ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 56 (also presented at TSRC 2018)

    Application and use of e-cigarettes HPHC methods for the analysis of heated tobacco products

    GILLMAN I.G.; HUMPHRIES K.E.; MARTIN A.M.; LASSITER S.; HILLDRUP J.
    Enthalpy Analytical, Inc., Durham, NC, U.S.A.
    The interest in e-cigarette research has resulted in the development of methods for the quantitative analysis of chemical constituents present in their aerosols. The emissions of e-cigarettes contain not only nicotine, propylene glycol, glycerin, water ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 63 (also presented at TSRC 2018)

    Challenges and opportunities in cigar science

    SMITH J.H.(1); AUBUCHON S.M.(1); WAGNER K.A.(1); McKINNEY W.J.(1); GILLMAN I.G.(2); STEVENS R.(3)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Enthalpy Analytical, Inc., Henrico, VA, U.S.A.; (3) ITG Brands LLC, Greensboro, NC, U.S.A.
    An independent Cigar Working Group has been formed by interested cigar stakeholders (e.g. manufacturers and testing laboratories). The goals of the Working Group are to explore opportunities for engagement with the Food and Drug Administration (FDA) on ...
  7. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 29 (also presented at TSRC 2016)

    Do temperature regulated e-cigarettes prevent the formation of thermal decomposition products under dry wick conditions?

    GILLMAN I.G.; HUMPHRIES K.E.
    Enthalpy Analytical Inc., Durham, NC, U.S.A.
    The study objective was to determine if temperature regulated e-cigarette (TR-EC) devices could reduce the formation of thermal decomposition products under simulated “dry wick” conditions. Three different TR-EC devices were evaluated under two conditions ...
  8. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 39

    The importance of method validation in the determination of 2,3-butanedione in e-liquids

    MARTIN A.(1); GILLMAN I.G.(2)
    (1) Enthalpy Analytical Inc., Richmond, VA, U.S.A.; (2) Enthalpy Analytical Inc., Durham, NC, U.S.A.
    There are many thousands of flavors potentially used in e-liquids. One particular flavoring of concern is 2,3-butanedione (diacetyl), the inhalation of which is associated with “popcorn lung”. In our experience, the determination of diacetyl and other ...
  9. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 37

    UPLC-MS separation and analysis of carbonyl compounds in e-liquids aerosol samples

    CARTER K.M.; MAINES H.; GILLMAN I.G.
    Enthalpy Analytical Inc., Richmond, VA, U.S.A.
    The popularity and regulation of electronic nicotine delivery systems (ENDS) has drawn attention to the chemical composition of the e-liquids used in, and aerosols formed by these devices. The possible presence of carbonyl compounds like formaldehyde, ...