1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 01 (also presented at TSRC 2018)

    FDA advance notice of proposed rulemaking for nicotine level of combusted cigarettes – feasibility for compliance via tobacco plant genetics?

    HIATT E.
    R.J. Reynolds Tobacco Co., Winston-Salem, NC, U.S.A.
    On March 16, 2018, the U.S. Food and Drug Administration (FDA) published an advance notice of proposed rulemaking (ANPRM) entitled “Tobacco Product Standard for Nicotine Level of Combusted Cigarettes.” The publication of an ANPRM solicits information...
  2. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, APPOST 04

    Pest and disease surveillance in flue-cured tobacco growing zones of India

    REDDY B.S.R.; SWAMY S.; MANI M.
    ITC Ltd, Agri Business Division, Research Department, Rajahmundry, A.P, India
    Pest and disease are major yield limiting factors in tobacco production and these biotic factors reduce the productivity besides affecting the quality of leaf. The control of these pest and diseases warrant more pesticide usage resulting in pesticide...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 01

    In vitro biological safety evaluation of cigarette smoke

    CHEN Xi(1,2); SHEN Y.(1,2); CHEN Hongyu(1,2); LIU F.(1,2); QI H.(3); JIMIN S.(3); TIMKO M.(4); FAN L.(1,2)
    (1) Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, P.R. China; (2) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (3) Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, P.R. China; (4) Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, U.S.A.
    Traditionally, toxicological evaluation of cigarette smoke has focused on the harmful chemical content of smoke. Harm-reduced cigarettes should not only refer to these chemical compounds, but also to the degree of the effect of whole smoke on human...
  4. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 15

    Fertigation of flue-cured tobacco with a combination of water soluble and straight fertilisers, for enhancing nitrogen and potassium use efficiency

    MAHESH M.N.V.A.; RAMAKRISHNA B.; MANI M.; SRINIVAS P.
    ITC Limited - Agri Business Division-ILTD, Research Department, Rajahmundry, Andhra Pradesh, India
    Nutrient application through drip irrigation (fertigation) with water soluble fertilisers, is an established practice to achieve nutrient use efficiency in flue-cured tobacco production. However, there has been a steady price escalation and erratic...
  5. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 65

    Management of Orobanche in flue-cured tobacco in India

    REDDY B.S.R.; SWAMY S.; MANI M.
    ITC Limited - Agri Business Division-ILTD, Research Department, Rajahmundry, Andhra Pradesh, India
    Orobanche (Orobanche cernua Loefl.) is a serious root parasite infesting tobacco roots in Northern Light Soil (NLS), Traditional and Mysore tobacco growing regions of India. The yield losses were ranging from 30-70% and plants show the symptoms of...
  6. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 45

    Status of benzo[a]pyrene in commonly consumed food products and in selected environments: a review

    TYAGI K.; DINESH T.K.; SUDESNA P.; SATHISH KUMAR D.
    ITC Limited, ITC Life Sciences & Technology Centre, Bengaluru, India
    Benzo[a]pyrene (B[a]P) is an extensively studied compound among the polycyclic aromatic hydrocarbons (PAHs) in commonly consumed products and in the environment. B[a]P is formed due to incomplete combustion of organic matter and commonly consumed...
  7. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 17

    Differentiating the effects of exposure to combustible and non-combustible tobacco product preparations using in vitro and ex vivo models

    PRASAD G.L.(1); ZACHARIAS W.(2); ARIMILLI S.(3)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, U.S.A.; (2) University of Louisville, Louisville, KY, U.S.A.; (3) Wake Forest University Baptist Health, Winston-Salem, NC, U.S.A.
    Exposure to cigarette smoke or its constituent phases induces a range of adverse cellular responses that include cytotoxicity, genotoxicity and inflammatory responses in several human cell culture models. The cellular effects of exposure to smokeless...
  8. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 26

    Contribution of manufacturing to variability in cigarette constituent levels

    HANNA S.N.(1); MORGAN W.T.(2); ROWE J.M.(2); OGDEN M.W.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, U.S.A.
    A range of tobacco and smoke analytes in cigarettes is of current regulatory interest. Understanding and communicating the variability associated with measurement of those analytes will aid regulators in making science-based decisions. Tobacco and...
  9. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 38

    Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations

    ARIMILLI S.(1); DAMRATOSKI B.E.(1); PRASAD G.L.(2)
    (1) Department of Microbiology & Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, U.S.A.; (2) R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking is known to adversely impact innate and adaptive immune responses, resulting in immunosuppression, which has been linked to increased susceptibility of smokers to microbial infections and higher incidences of cancer relative...
  10. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 77

    In vitro toxicity testing of tobacco products: the CORESTA In Vitro Toxicity Testing of Tobacco Smoke Task Force

    BOMBICK B.
    R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.
    Results from in vitro toxicity tests have been reported for several decades. Methods for several in vitro toxicity tests have been formalised, accompanied by both national and international guidelines for toxicity test batteries. Cigarette smoke...