1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, APPOST 11

    Field trials with low nicotine tobacco varieties developed by conventional breeding technique: first results

    MALPICA A.(1); EVANS W.(2); ARCHIBALD C.(3); SCOTT L.(4); GARWE D.(5); CHAMANGO A.M.Z.(6); DORLHAC de BORNE F.(7); COLARD S.(8)
    (1) Bergerac Seed and Breeding, Bergerac, France; (2) Imperial Tobacco South Africa Pvt. Ltd, Umhlanga, Durban, South Africa; (3) Alliance One International Services, Camberley, Surrey, U.K.; (4) Universal Leaf Tobacco Co., Richmond, VA, U.S.A.; (5) Tobacco Research Board (TRB), Harare, Zimbabwe; (6) Agricultural Research & Extension Trust (ARET), Lilongwe, Malawi; (7) Imperial Tobacco Limited, Bergerac, France; (8) SEITA - Imperial Brands plc, Paris, France
    In 2015, the World Health Organisation (WHO) Study Group on Tobacco Product Regulation (“TobReg”) issued an advisory note recommending a strategy of reducing nicotine in tobacco to substantially lower levels of 0.4 mg/g. In the U.S., the Food and...
  2. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, APPOST 24

    Development and evaluation of tobaccos engineered for high leaf-oil accumulation

    PERRY J.P.(1); HILDBRAND D.(2); YUAN L.(1); PETRIE J.(3); GREEN A.(3); LEITA B.(3)
    (1) University of Kentucky, KTRDC, Lexington, KY, U.S.A.; (2) University of Kentucky, Department of Plant and Soil Sciences, Lexington, KY, U.S.A.; (3) CSIRO Agriculture & Food, Canberra, Australia
    Demand for plant-derived oil (triacylglycerols, TAG) commodities is expected to more than double in coming decades due to increasing food oil requirements. Furthermore, the emerging shift to use renewable feedstock for fuels and industrial chemicals...
  3. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, APPOST 27

    Critical period for weed control in flue-cured tobacco

    INMAN M.D.; VANN M.C.; FISHER L.R.; JORDAN D.L.
    North Carolina State University, Department of Crop & Soil Sciences, Raleigh, NC, U.S.A.
    Field experiments were conducted to determine the critical period for weed control (CPWC) in flue-cured tobacco. This period consists of two separately measured timings; a critical weed-free period and a critical timing for the weed removal period....
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 05

    Examining intra-individual and inter-individual variability of plasma nicotine PK parameters in e-vapor use by adult cigarette smokers in three studies

    LIANG Qiwei; ZHAO Yuxi; WANG Jingzhu; BLACK R.
    Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    Pharmacokinetic studies are often used to assess the rate and amount of nicotine delivery into the bloodstream during product use. Knowledge about intra-individual and inter-individual variability of pharmacokinetic (PK) parameters is important in...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 12 (also presented at TSRC 2018)

    Characterization of the Vitrocell® high throughput exposure modules using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(2); SEYMOUR A.(2); HOLLINGS M.(2); BOMBICK B.(1)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    The development of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessment of freshly generated whole smoke and aerosol from combustible and tobacco heating products (THP) as well as electronic nicotine delivery systems...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 13 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 1. Mouse lymphoma assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); LLOYD M.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from different tobacco and nicotine delivery products was assessed...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 14 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 2. In Vitro micronucleus assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); WHITWELL J.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support toxicological evaluations of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 28 (also presented at TSRC 2018)

    Non-targeted analysis for differential screening of tobacco samples

    MILLER J.H.; PITHAWALLA Y.B.; DANIELSON T.L.; XU Dongmei
    Altria Client Services LLC, Richmond, VA, U.S.A.
    Non-targeted analysis of samples has broad applications across the food industry and in the evaluation of natural products. For example, this approach has been used by the food industry to evaluate purity and quality of fruit juices, olive oil and...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 29 (also presented at TSRC 2018)

    Toxicological assessment of e-liquid formulations using in vitro genotoxicity and cytotoxicity assays

    COFFA B.G.; DOSHI U.; ZHANG J.; McKINNEY W.J.; LEE K.M.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In the electronic nicotine delivery systems (ENDS) Premarket Tobacco Application (PMTA; 2016) Draft Guidance, the U.S. Food and Drug Administration (FDA) recommends a full assessment of the toxicological profile associated with new tobacco products,...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 30

    Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

    ISKANDER A.(1); STEINER S.(1); MAJEED S.(1); KONDYLIS A.(1); XIANG Yang(1); ZANETTI F.(1); FRENTZEL S.(1); MARTIN F.(1); PEITSCH M.C.(1); DOSHI U.(2); McKINNEY W.J.(2); LEE K.M.(2); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond VA, U.S.A.
    Considerable attention has been given toward the reduced risk potential of e-cigarettes (e-cigs). Most in vitro studies have focused on testing e-liquid formulations directly on submerged 2D cultures. Here, we examined the effects of exposure to the...