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  1. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 62

    Overview of in vitro methods used to assess e-cigarettes based on “Toxicity Testing in 21st Century” principles

    SIMMS L.(1); STEVENSON M.(1); CZEKALA L.(1); TSCHIERSKE N.(1); WALELE T.(2)
    (1) Imperial Tobacco Ltd, Bristol, U.K.; (2) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    When the National Academies of Sciences released “Toxicity Testing in the 21st Century: A Vision and a Strategy” a new toxicological paradigm was created, focusing on the use of human cell lines and the disruption of key cellular pathways. In keeping...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2013, Seville, ST 19

    Human mouth-level transfer rate of menthol, 1.8-cineole and nicotine from Swedish pouched snus

    TROUDE V.(1); GADOIS-POMMEREUL S.(1); CLARKE A.(2); SIMMS L.(2)
    (1) SEITA, Imperial Tobacco Group, Fleury-les-Aubrais, France; (2) Imperial Tobacco Limited, Bristol, U.K.
    To facilitate the development of a transfer model which can be used to estimate human exposure to flavour and tobacco constituents, a human in vivo study involving 198 Swedish active snus users was conducted. All subjects agreed to participate in the...