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182 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 09

    The ABOUT™ Toolbox: toward the development of consumer-reported outcome measures that matter

    CHREA C.(1); SPIES E.(1); AFOLALU E.(1); BACSO A.(1); CLERC E.(1); MAINY N.(1); BINGGELI P.(1); WEITKUNAT R.(1); ACQUADRO C.(2); SALZBERGER T.(3); CANO S.(4); ABETZ-WEBB L.(5); ROSE J.(6)
    (1) PMI R&D, Philip Morris Products S.A., Neuchatel, Switzerland; (2) Mapi, an ICON plc Company, Lyon, France; (3) University of Economics and Business, Vienna, Austria; (4) ScaleReport, Ltd, Stotfold, U.K.; (5) Patient-Centered Outcomes Assessments, Ltd, Macclesfield Cheshire, U.K.; (6) Rose Research Center, Raleigh, U.S.A.
    Tobacco harm reduction promotes the substitution of reduced-risk products (RRPs) for cigarettes by adult smokers who would otherwise continue to smoke, while preventing RRP initiation among non-users. To operationalize this public health strategy,...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 11

    Development and validation of the ABOUT™–Dependence measurement instrument to assess perceived dependence on tobacco and nicotine products

    AFOLALU E.(1); CHREA C.(1); SALZBERGER T.(2); ABETZ-WEBB L.(3); CANO S.(4); WEITKUNAT R.(1); ROSE J.(5)
    (1) PMI R&D, Philip Morris Products S.A., Neuchatel, Switzerland; (2) University of Economics and Business, Vienna, Austria; (3) Patient-Centered Outcomes Assessments, Ltd, Macclesfield Cheshire, U.K.; (4) Modus Outcomes, Letchworth Garden City, U.K.; (5) Rose Research Center, Raleigh, U.S.A.
    The development of the ABOUT™–Dependence measurement instrument was initiated to enable assessment of perceived dependence associated with the use of different tobacco and nicotine products (TNPs) and in users of multiple TNPs. We initially developed...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 12

    Review of current methodologies in evaluating abuse liability of nicotine and tobacco products in the U.S. regulatory environment

    EVANS S.(1); KONG M.C.(2); CAMPBELL L.(2); SHERWOOD N.(3); PRASAD K.(4)
    (1) Turning Point Brands, Louisville, KY, U.S.A.; (2) Altasciences Clinical Research, Laval, Canada; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) British American Tobacco, R&D, Millbrook, Southampton, U.K.
    Traditional definitions of abuse and misuse do not apply to a consumer product such as tobacco that consumers essentially use ‘as intended’. In contrast to pharmaceutical products, a guidance for abuse liability testing of nicotine and tobacco...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 13

    Importance of e-liquid preparation and stability characterization for a combinatorial safety assessment approach of flavors in e-liquids

    GLABASNIA A.(1); DIANA P.(1); SMITH C.(2); MILLER J.H.(2); BIASIOLI M.(1); FRAUENDORFER F.(1); SCIUSCIO D.(1); MARTIN E.(1); POSPISIL P.(1); GUY P.(1); VANSCHEEUWIJCK P.(1); HOENG J.(1); KUMAR A.(2); LEE K.M.(2)
    (1) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) Altria Client Services LLC, Richmond, VA, U.S.A.
    Numerous flavorings are generally recognized as safe for use in food, but there is limited information available to evaluate their potential toxicity by inhalation. Consequently, gaining information on individual flavor safety levels is of...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 18

    Human precision-cut lung slices as a screening tool: increased throughput, cryopreservation, and detection of DNA adducts for next generation tobacco product evaluation

    BEHRSING H.P.(1); DESAI P.(1); AMIN K.(2); BALBO S.(3); HECHT S.S.(2); SHEEHAN D.(1); CASTRO N.(1); ALLEN D.(4)
    (1) Institute for In Vitro Sciences, Inc., Gaithersburg, MD, U.S.A.; (2) University of Minnesota, Division of Environmental Health Sciences, Minneapolis, MN, U.S.A.; (3) University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, U.S.A.; (4) Integrated Laboratory Systems, Inc., Morrisville, NC, U.S.A.
    Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the many chemicals requiring hazard assessment, such as next generation tobacco product (NGTP) ingredients. Human precision-cut lung...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 19

    In vitro biological impact evaluation of whole cigarette smoke by using pathway-based approach

    CHEN H.(1,2); CHEN X.(1,2); SHEN Y.(3); LIU F.(1,2); YIN X.(1); LIU L.(1); TIMKO M.(4); QI H.(5); FAN L.(1,2,3)
    (1) Institute of Crop Science, Zhejiang University, Hangzhou, P.R. China; (2) Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, P.R. China; (3) Institute of Bioinformatics, Zhejiang University, Hangzhou, P.R. China; (4) Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, U.S.A.; (5) Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, P.R. China
    Harm-reduced cigarettes have been greatly developed to minimize the negative impact of smoking on health. However, the practical effects of such products are still under debate. Along with the application of high-throughput sequencing technologies...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 31 (also presented at TSRC 2019)

    Impact of device variability on the determination of aldehyde compounds in e-cigarette emissions

    GILLMAN I.G.; PENNINGTON A.S.C.; HUMPHRIES K.E.
    Enthalpy Analytical, LLC, Durham NC, U.S.A.
    The determination of aldehyde compounds (formaldehyde, acetaldehyde and acrolein) in e-cigarette emissions has been widely reported in scientific literature. Recent reports have focused on the contribution of flavor compounds in e-liquids and on the...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 36 (also presented at TSRC 2019)

    HPHC market map study for U.S. machine-made cigars – Part 1: Physical properties, filler and smoke HPHC variability

    WAGNER K.A.; MORTON M.J.; OLEGARIO R.M.; BAKER L.L.; SMITH J.H.
    Altria Client Services LLC, Richmond, VA 23219, U.S.A.
    Market map studies have been used in the cigarette industry for many years to aid in the characterization of the marketplace. These studies provide comparative values and predictive models for aiding in the assessment of other products. However, the...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 37 (also presented at TSRC 2019)

    HPHC market map study for U.S. machine-made cigars – Part 2: Predictive models

    MORTON M.J.; WAGNER K.A.; OLEGARIO R.M.; BAKER L.L.; SMITH J.H.
    Altria Client Services LLC, Richmond, VA 23219, U.S.A.
    Market map studies have been used in the cigarette industry for many years to aid in the characterization of the marketplace. These studies provide comparative values and predictive models for aiding in the assessment of other products. However, the...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 38 (also presented at TSRC 2019)

    Optimized method for determination of selective phenolic compounds in cigarette and cigar smoke by UHPLC-FLD

    JIN X.C.; HURST T.J.; WAGNER T.J.
    Altria Client Services, Research, Development & Regulatory Affairs, Richmond, VA, U.S.A.
    Phenolic compounds, including phenol, catechol, and o-, m-, and p-cresol are included in the “Established List of the Chemicals and Chemical Compounds Identified by the FDA as Harmful and Potentially Harmful Constituents [HPHCs] in Tobacco Products...