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6 results

  1. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 070

    Genetic approaches and resources for enabling compliance to proposed NNN standards

    DEWEY R.E.(1); LEWIS R.S.(1); LU Jianli(1); BOVET L.(2); GOEPFERT S.(2); CAMPANONI P.(2)
    (1) North Carolina State University, Raleigh, NC, USA; (2) Philip Morris International, Neuchatel, Switzerland
    Tobacco-specific nitrosamines (TSNAs) are formed through the nitrosation of tobacco alkaloids. Over the past decade, we have demonstrated how altering the genetics of the tobacco plant can result in dramatic reductions in TSNA formation. This has been ...
  2. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 03

    Molecular biology-based approaches for facilitating compliance of future tobacco products in an FDA regulatory environment

    DEWEY R.E.; LEWIS R.S.
    North Carolina State University, Raleigh, North Carolina, USA
    Passed in 2009, the Family Smoking Prevention and Tobacco Control Act granted the U.S. Food and Drug Administration (FDA) the authority to regulate tobacco products. Among the powers given the FDA in this landmark legislation was the authority to define ...
  3. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 13

    Accumulation of nicotine and nornicotine enantiomers in leaf of nicotine demethylases mutants during growth and curing

    CAI B.(1); JACK A.M.(1); LEWIS R.S.(2); DEWEY R.E.(2); JI H.(1); BUSH L.P.(1)
    (1) University of Kentucky, Lexington, KY, USA; (2) North Carolina State University, Raleigh, NC, USA
    Nicotine metabolism in tobacco plants is mostly through N-demethylation, resulting in nornicotine. There are three functional nicotine demethylases CYP82E4 (E4), CYP82E5v2 (E5) and CYP82E10 (E10) in tobacco. In this study, we investigated the nicotine and ...