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4 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 018

    Development of a small airway lung model using microfluidic lung-on-a-chip device

    MAKENA P.(1); PRASAD G.L.(1); GORDON D.(2); HAITHCOCK D.(2); PRABHAKARPANDIAN B.(2); PANT K.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) SynVivo Inc., Huntsville, AL, USA
    Current in vitro models of small airway lung, which have primarily been developed on a transwell membrane with epithelial cells cultured at air liquid interface (ALI), lack certain elements of the in vivo physiology such as fluidic shear and...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 019

    Microfluidic small airway lung model for toxicity screening of tobacco products

    MAKENA P.(1); PRASAD G.L.(1); GORDON D.(2); HAITHCOCK D.(2); PRABHAKARPANDIAN B.(2); PANT K.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) SynVivo Inc., Huntsville, AL, USA
    Physiologically relevant in vitro lung models are valuable tools to accurately assess the cytotoxicity of inhaled toxicants. Epithelial cells cultured in transwells do not accurately represent the cellular architecture, physiology, and fluidic shear...
  3. TSRC, Tob. Sci. Res. Conf., 2011, 65, abstr. 22

    Cell transformation activity of cigarette smoke condensate in Bhas 42 ASSAY.

    PANT K.(1); BRUCE S.W.(1); GAIROLA C.G.(2)
    (1) BioReliance Corp Rockville, MD, USA; (2) University of Kentucky Medical Center, Lexington, KY, USA
    Cell transformation assays have been commonly used to predict chemical carcinogenicity. Using v-Ha-ras transfected BALB/c3T3 (Bhas 42) cells, Sasaki and coworkers (2010, 2011) have recently validated a sensitive short-term assay that simulates the...