Search Results

11 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 010 (also presented at CORESTA 2018)

    Evaluation of novel, oral tobacco-derived nicotine products for HPHCs

    DANIELSON T.L.; McFARLANE C.B.; BROWN A.P.; JIN Xiaohong; WILKINSON C.T.; PITHAWALLA Y.B.; McKINNEY W.J. Jr.
    Altria Client Services LLC, Richmond, VA, USA
    VERVE® Discs and Chews are oral, non-dissolvable, tobacco-derived nicotine products. In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule to deem e-cigarettes, cigars and all other tobacco products, including VERVE® to be subject ...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 011 (also presented at CORESTA 2018)

    Quantification of nicotine related impurities in novel, oral tobacco-derived nicotine products

    DANIELSON T.L.; McFARLANE C.B.; NOE M.R.; PITHAWALLA Y.B.; McKINNEY W.J. Jr.
    Altria Client Services LLC, Richmond, VA, USA
    VERVE® Discs and Chews are oral, non-dissolvable, tobacco-derived nicotine products. In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule to deem e-cigarettes, cigars and all other tobacco products, such as VERVE®, to be subject to ...
  3. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 021 (also presented at CORESTA 2018)

    Non-targeted analysis for differential screening of tobacco samples

    MILLER J.H. IV; PITHAWALLA Y.B.; DANIELSON T.L.; XU Dongmei
    Altria Client Services LLC, Richmond, VA, USA
    We have developed a non-targeted liquid chromatography mass spectrometry method for the analysis of tobacco samples which is able to differentiate between types of tobacco and tobacco leaf blends. Non-targeted analysis of samples has broad applications ...
  4. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 064 (also presented at CORESTA 2018)

    Non-targeted analysis using gas chromatography mass spectrometry to evaluate stability of e-vapor products

    CROSSWHITE M.; SHAH N.; NOE M.; SUAREZ C.; MILLER J.H. IV; PITHAWALLA Y.B.; GARDNER W.P.
    Altria Client Services LLC, Richmond, VA, USA
    In the newly regulated landscape of tobacco products there is an increasing need to fully characterize the chemical composition of aerosol in new products. Although aerosol from e-vapor products are considerably less complex than aerosols from Heat-Not ...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 073 (also presented at CORESTA 2018)

    Modification of standardized methods for the measurement of nicotine in very low nicotine content cigarettes

    BROWN A.P.(1); MELVIN M.S.(1); PITHAWALLA Y.B.(1); SMITH J.H.(1); WAGNER K.A.(1); LIU Hui(2); MASON K.(2); PIEROTTI J.(2); STUTT K.(2)
    (1) Altria Client Services LLC, Richmond, VA, USA; (2) Eurofins Lancaster Professional Scientific Staffing, Richmond, VA, USA
    In March 2018, the US Food and Drug Administration (FDA) issued an advanced notice of proposed rulemaking (ANPRM) for a nicotine product standard that would limit the amount of nicotine in combusted tobacco products. FDA requested comments regarding ...
  6. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 084 (also presented at CORESTA 2018)

    Evaluation of the formaldehyde hemiacetals and acetals relevant to electronic cigarettes

    JIN Xiaohong Cathy; AVERY K.C.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; MELVIN M.S.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, USA
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for Electronic Nicotine Delivery Systems (ENDS). In this draft guidance, the FDA recommends reporting toxicants in ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 087 (also presented at CORESTA 2018)

    Structure-activity relationships of propylene glycol, glycerin, and select analogs for carbonyl thermal degradation products

    MELVIN M.S.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, USA
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for Electronic Nicotine Delivery Systems. In this draft guidance, the FDA recommends reporting several carbonyl ...
  8. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 129 (also presented at CORESTA SSPT2017)

    A computational model to characterize the Vitrocell® cell exposure system for evaluation of aerosols

    CASTRO N.(1); ROSTAMI A.A.(1); OLDHAM M.J.(1); PITHAWALLA Y.B.(1); LUCCI F.(2); KUCZAJ A.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    In vitro exposure systems can be used as tools for toxicological assessment of e-cigarette aerosols. The VITROCELL® exposure system is designed such that exposure of cell cultures to the aerosol occurs at the air/liquid interface, which is relevant to e ...
  9. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 09 (also presented at CORESTA 2016)

    A proposed approach for modeling HPHC yields

    ROSTAMI A.A.; PITHAWALLA Y.B.; HANNEL T.; MORTON M.J.; WANG J.; GANNON T.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, USA
    To ensure quality, consistency and supply security of its portfolio over time, a company may need to make changes that affect all or much of its portfolio of products. Among other requirements, prior to introducing a changed tobacco product into ...
  10. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 66

    Computational modeling of e-vapor aerosol dynamics and deposition in respiratory tract

    ROSTAMI A.A.(1); CASTRO N.(1); PITHAWALLA Y.B.(1); OLDHAM M.J.(1); LI W.(1); ZHANG J.(2); YU F.(3)
    (1) Altria Client Services LLC, Richmond, VA, USA; (2) Lancaster Laboratories, c/o Altria Client Services LLC, Richmond, VA, USA; (3) Oklahoma State University, Stillwater, OK, USA
    It is important for risk assessment of e-vapor products to understand: (1) how much of each aerosol constituent is deposited in the buccal cavity, upper and lower respiratory tracts? and (2) in what form (vapor or liquid) each aerosol constituent is ...