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4 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 009 (also presented at CORESTA 2018)

    Toxicological assessment of e-liquid formulations using in vitro genotoxicity and cytotoxicity assays

    COFFA B.G.; DOSHI U.; ZHANG Jingjie; McKINNEY W.J.; LEE K.M.
    Altria Client Services LLC, Richmond, VA, USA
    In the Electronic Nicotine Delivery Systems (ENDS) Premarket Tobacco Application (PMTA; 2016) Draft Guidance, the FDA recommends a full assessment of the toxicological profile associated with new tobacco products, using in vitro toxicology (e.g., ...
  2. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 007

    Neutral red uptake cytotoxicity assay in A549 cells under different culture conditions

    COFFA B.G.(1); DOSHI U.(1); ZHANG Jingjie(1); McKINNEY W.J.(1); LEE K.M.(1); DESAI P.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) Enthalpy Analytical, Richmond, VA, USA
    The OECD guideline (TG129) recommends mouse fibroblasts (3T3) & normal human epidermal keratinocytes (NHK) for performing in vitro cytotoxicity assays but also mentions limitations of these cells, such as having little to no metabolic capacity or ...
  3. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 100 (also presented at CORESTA SSPT2017)

    Electronic cigarette aerosol dynamics in a physical model of the adult human oral/pharyngeal cavity

    LI Weiling(1); WANG Qiang(2); CASTRO N.(1); ZHANG Jingjie(1); PITHAWALLA Y.(1); OLDHAM M.J.(1); LIPOWICZ P.(1); ROSTAMI A.A.(1)
    (1) Altria Client Services Richmond, VA, USA; (2) Eurofins Lancaster Laboratories, c/o Altria Client Services, Richmond, VA, USA
    The objective of this work is to generate experimental data to validate a computational fluid dynamic (CFD) model for e-cigarette aerosol deposition. An adult human oral/pharyngeal wet walled hollow physical model has been developed for this purpose. The ...