Search Results

7 results

  1. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 067

    Characterization of smokeless tobacco products extracted with different solvents for in vitro testing

    ZHANG JINGJIE (1); DOSHI U.(1); THAIKOOTTATHIL J.(1); LEE K.M.(1); WOLZ R.L.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) Enthalpy Analytical, Richmond, VA, USA
    Unlike cigarettes, there are no standardized methods available for preparing extracts from smokeless tobacco (SLT) products for in vitro toxicological evaluation. Methods are available for Harmful and Potentially Harmful constituents (HPHCs) ...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 105

    Preclinical testing of flavors in e-vapor products - Part 3: In vitro cytotoxicity and genotoxicity of representative flavor mixtures

    DOSHI U.B.; ZHANG JINGJIE; KUMAR A.; LEE K.M.
    Altria Client Services, Richmond, VA, USA
    Flavor compounds “generally recognized as safe” for oral consumption are commonly used in inhalable e-vapor products for which insufficient safety data exists. The hazard characterization of each flavor and various flavor mixtures is resource and time ...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 106

    Preclinical testing of flavors in e-vapor products - Part 4: Flavor transfer from the liquid to the aerosol for inhalation exposure

    ZHANG Jingjie; SMITH C.; ANDERSON C.; McCUTCHEON N.; MILLER J.H.; LEE K.M.
    Altria Client Services, Richmond, VA, USA
    Many flavor compounds used in e-liquids are generally recognized as safe (GRAS) for oral consumption. However, the respiratory effects of flavors in e-vapor aerosols are unknown. Preclinical inhalation studies can provide toxicity data to assess the ...
  4. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 009 (also presented at CORESTA 2018)

    Toxicological assessment of e-liquid formulations using in vitro genotoxicity and cytotoxicity assays

    COFFA B.G.; DOSHI U.; ZHANG Jingjie; McKINNEY W.J.; LEE K.M.
    Altria Client Services LLC, Richmond, VA, USA
    In the Electronic Nicotine Delivery Systems (ENDS) Premarket Tobacco Application (PMTA; 2016) Draft Guidance, the FDA recommends a full assessment of the toxicological profile associated with new tobacco products, using in vitro toxicology (e.g., ...
  5. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 007

    Neutral red uptake cytotoxicity assay in A549 cells under different culture conditions

    COFFA B.G.(1); DOSHI U.(1); ZHANG Jingjie(1); McKINNEY W.J.(1); LEE K.M.(1); DESAI P.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) Enthalpy Analytical, Richmond, VA, USA
    The OECD guideline (TG129) recommends mouse fibroblasts (3T3) & normal human epidermal keratinocytes (NHK) for performing in vitro cytotoxicity assays but also mentions limitations of these cells, such as having little to no metabolic capacity or ...
  6. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 100 (also presented at CORESTA SSPT2017)

    Electronic cigarette aerosol dynamics in a physical model of the adult human oral/pharyngeal cavity

    LI Weiling(1); WANG Qiang(2); CASTRO N.(1); ZHANG Jingjie(1); PITHAWALLA Y.(1); OLDHAM M.J.(1); LIPOWICZ P.(1); ROSTAMI A.A.(1)
    (1) Altria Client Services Richmond, VA, USA; (2) Eurofins Lancaster Laboratories, c/o Altria Client Services, Richmond, VA, USA
    The objective of this work is to generate experimental data to validate a computational fluid dynamic (CFD) model for e-cigarette aerosol deposition. An adult human oral/pharyngeal wet walled hollow physical model has been developed for this purpose. The ...