Search Results

35 results

  1. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 029

    Comprehensive insights into tobacco smoke using flow-modulated GCxGC-TOF MS

    LEMONS M.(1); McGREGOR L.(2); GREEN B.(2); BUCHANAN A.(2); EDWARDS M.(3)
    (1) Markes International, Sacramento, CA, USA; (2) SepSolve Analytical, Peterborough, UK; (3) SepSolve Analytical, Ontario, Canada
    From an analytical perspective, there is much that remains to be learnt about the composition of cigarette smoke, because of its high degree of complexity – tobacco smoke is thought to contain thousands of components across multiple chemical classes and ...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 044

    Abuse liability of very low nicotine content cigarettes with characterization of nicotine exposure profiles in adult smokers

    LEVY-COOPERMAN N.(1); SHRAM M.J.(1); KELSH D.(2); VINCE B.(2); CARMINES E.(3)
    (1) Altreos Research Partners, Toronto, ON, Canada; (2) Altasciences/Vince and Associates, Overland Park, KS, USA; (3) Carmines Consulting, Scottsdale, AZ, USA
    Objectives: In 2017, FDA announced the intention to explore limiting nicotine in cigarettes to minimal/non-addictive levels. Research indicates that reduced nicotine content would potentially limit reinforcing effects of cigarettes. We conducted 2 studies ...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 102 (also presented at CORESTA SSPT2019)

    Novel application of differential ion mobility spectrometry-tandem mass spectrometry for improved assay selectivity and sensitivity in the quantitative determination of total NNN total NNAL and 2- / 3-HPMA in human urine

    PLOMLEY J.
    Altasciences, Laval, Canada
    Differential Ion Mobility Spectrometry (DMS) has recently emerged as an orthogonal gas-phase ion separation technique which, when interfaced between liquid chromatography (LC) and Tandem Mass Spectrometry (MS/MS), promises improvements in both assay ...
  4. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 049

    Assessment of in vitro toxicity/genotoxicity of ends and combustible products

    JORDAN K.(1); BOMBICK B.(1); COOPER B.(1); LEVERETTE R.(1); SHUTSKY T.(1); WEST C.(1); STRASSER J.(1); ROUND E.(1); MARANO K.M.(1); MOMIN R.(2); TRIVEDI A.(2); WAGSTAFF W.(2); BRUCE S.(3); DAKOULAS E.(3); ROY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labstat International ULC, Kitchener, ON, Canada; (3) BioReliance Corp, Rockville, MD, USA
    In May 2016, the U.S. Food and Drug Administration Center for Tobacco Products (CTP) issued draft guidance for Premarket Tobacco Product Applications (PMTA) for Electronic Nicotine Delivery Systems (ENDS), which recommends inclusion of in vitro toxicology ...
  5. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 047

    The impact of 2, 4-dinitrophenylhydrazine (DNPH) background in the determination of carbonyls compounds in e-cigarette vapor

    DONISA C.; JOZA P.; RODRIGUEZ-LAFUENTE A.; RICKERT W.S.
    Labstat International, Kitchener, ON, Canada
    Carbonyl compounds, are known to be present in some e-liquid formulations and can be formed during aerosol generation. Analysis of these compounds, as their hydrazones (2,4-dinitrophenylhydrazine; DNPH) are routinely performed using high performance ...
  6. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 087

    Analysis of organic acid content in e-liquids and e-cigarette aerosol by high performance liquid chromatography – ultraviolet detection (HPLC-UV)

    RODRIGUEZ-LAFUENTE A.; LODEVICO R.; SHARIFI M.; JOZA P.; RICKERT W.S.
    Labstat International, Kitchener, ON, Canada
    Weak organic acids can be used as preservative agents, potentially affecting the stability of e-cigarette solutions. However, they can also impact characteristics like the aroma and taste of aerosols. The objective of this study was to develop and ...