Search Results

30 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 049

    Assessment of in vitro toxicity/genotoxicity of ends and combustible products

    JORDAN K.(1); BOMBICK B.(1); COOPER B.(1); LEVERETTE R.(1); SHUTSKY T.(1); WEST C.(1); STRASSER J.(1); ROUND E.(1); MARANO K.M.(1); MOMIN R.(2); TRIVEDI A.(2); WAGSTAFF W.(2); BRUCE S.(3); DAKOULAS E.(3); ROY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labstat International ULC, Kitchener, ON, Canada; (3) BioReliance Corp, Rockville, MD, USA
    In May 2016, the U.S. Food and Drug Administration Center for Tobacco Products (CTP) issued draft guidance for Premarket Tobacco Product Applications (PMTA) for Electronic Nicotine Delivery Systems (ENDS), which recommends inclusion of in vitro toxicology ...
  2. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 047

    The impact of 2, 4-dinitrophenylhydrazine (DNPH) background in the determination of carbonyls compounds in e-cigarette vapor

    DONISA C.; JOZA P.; RODRIGUEZ-LAFUENTE A.; RICKERT W.S.
    Labstat International, Kitchener, ON, Canada
    Carbonyl compounds, are known to be present in some e-liquid formulations and can be formed during aerosol generation. Analysis of these compounds, as their hydrazones (2,4-dinitrophenylhydrazine; DNPH) are routinely performed using high performance ...
  3. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 087

    Analysis of organic acid content in e-liquids and e-cigarette aerosol by high performance liquid chromatography – ultraviolet detection (HPLC-UV)

    RODRIGUEZ-LAFUENTE A.; LODEVICO R.; SHARIFI M.; JOZA P.; RICKERT W.S.
    Labstat International, Kitchener, ON, Canada
    Weak organic acids can be used as preservative agents, potentially affecting the stability of e-cigarette solutions. However, they can also impact characteristics like the aroma and taste of aerosols. The objective of this study was to develop and ...
  4. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 46

    Cambridge filter pad collection efficiency of menthol from e-cigarette aerosols – an investigative study

    SHARIFI M.; JOZA P.; LODEVICO R.; RICKERT W.
    Labstat International ULC, Kitchener, ON Canada
    The demand for developing analytical protocols for the analysis of e-cigarette emissions has been rapidly increasing in recent years. A majority of methodologies currently used for the charaterization of e-cigarette aerosols are derived from approaches ...
  5. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 64

    Analysis of 21 carbonyl compounds in e-liquids and e-aerosols by gas chromatography-mass spectrometry after PFBHA derivatization

    BAO M.; JOZA P.; RICKERT W.
    Labstat International ULC, Kitchener, ON, Canada
    The quantification of carbonyl compounds in e-liquids and e-aerosols is an important tool for the evaluation of new products, in order to explore ways to reduce emissions and estimate potential exposure. In response to this need, a simple and selective ...
  6. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 110

    Quantitative biomonitoring of urine mutagenicity: an alternative to classical ames test

    ISLAM R.(1); ISLAM C.(2)
    (1) Celerion Inc., Lincoln, NE USA; (2) Somru BioScience Inc., Charlottetown, Canada
    For more than 30 years the Ames test has been a widely used in-vitro method for the biomonitoring of urine mutagenicity due to exposure to tobacco products. Briefly, the Ames’ test detects point mutations and frame shifts based on the reversion of ...
  7. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 28

    Determination of nine volatile nitrosamines and hydroxy-nitrosamines in cigarette filler and mainstream tobacco smoke using isotope-dilution LC-MS/MS

    SHARIFI M.; JOZA P.; RICKERT W.
    Labstat International ULC, Kitchener, Ontario, Canada
    Volatile nitrosamines (VNA) and N-nitrosodiethanolamine (NDELA) in tobacco and tobacco smoke have been traditionally quantified using multi-step procedures involving either chemoluminescence (GC-TEA) or more recently mass spectrometric (GC-MS) techniques. ...