Search Results

10 results

  1. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 097

    Methodology to determine the particle size distribution, mean, and standard deviation from sieve data

    ST. CHARLES F.K.(1); MORGAN W.T.(2)
    (1) St. Charles Consultancy, Lewisville, NC, USA; (2) RAI Services, Winston-Salem, NC, USA
    A method is described which allows the mean and standard deviation of particle size to be estimated from sieve data. The results can be used to calculate and plot the particle size distribution, the cumulative distribution, percentiles, and guide...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 013

    Method development for pH analysis of ends aerosol and e-liquid

    HEFNER T.(1); ST. CHARLES F.K.(2); ANDERSON J.(3)
    (1) R.J. Reynolds Tobacco Company, Winston Salem, NC, USA; (2) St.Charles Consultancy, Winston Salem, NC, USA; (3) Eurofins Lancaster Labs, Winston Salem, NC, USA
    E-liquids are hygroscopic, non-aqueous liquids containing a small amount of water (~3-15%). When the pH of a non-aqueous liquid is measured using conventional methods and calibration buffers, the value can only be regarded as an "apparent pH". This...
  3. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 057

    AKR1C1 as a biomarker for differentiating the biological effects of combustible from non-combustible tobacco products

    TRAN Q.T.(1); WOO S.(2); HENDERSON D.(2); GAO H.(3); ZACHARIAS W.(3); LIU G.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Axio Research, Seattle, WA, USA; (3) University of Louisville School of Medicine, Louisville, KY, USA
    Smoking has been established as a major risk factor for developing oral squamous cell carcinoma (OSCC), but less attention has been paid to the effects of smokeless tobacco products. Our objective is to identify potential biomarkers to distinguish...
  4. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 77

    A robust method for evaluating the pH of e-liquids

    ST. CHARLES F.K.(1); MOLDOVEANU S.(2); SCOTT W.(2)
    (1) St. Charles Consultancy, Lewisville, NC, USA; (2) R.J. Reynolds Tobacco Co., Winston-Salem, NC, USA
    The measurement of pH is one of the simplest and most common analytical methods practiced in the laboratory. The pH-meter is calibrated using certified buffers, the electrode is placed in the solution, and if a reading is obtained, the value is used....
  5. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 40

    Nicotine activity in tobacco

    ST.CHARLES F.K.(1); MOLDOVEANU S.C.(2)
    (1) St. Charles Consultancy, Lewisville, North Carolina, USA; (2) R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA
    The vapor pressure of pure nicotine has been reported in the literature. However, to the best of our knowledge, measurements of the vapor pressure of nicotine from tobacco have not been reported. Nicotine migration from tobacco to cigarette filters...
  6. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 38

    The migration during storage, transfer to smoke, and filtration efficiency of nicotine, glycerin, and propylene glycol in cigarettes.

    ST. CHARLES F.K.(1); MOLDOVEANU S.C.(2); MILLS H.D.(2); ANDRESEN N.P.(2)
    (1) St.Charles Consultancy, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco Co., Winston Salem, NC, USA
    This study evaluated the migration during storage, transfer to smoke and filtration of nicotine, glycerin and propylene glycol (PG) for cigarettes with cellulose acetate/triacetin filters. Filtration efficiency (FE) and smoke yields were studied for...
  7. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 30

    Combusted, but not smokeless tobacco product preparations, cause DNA damage in human oral cavity cells

    ZACHARIAS W.(1); HONG GAO(1); PRASAD G.L.(2)
    (1) Brown Cancer Center, Univ. of Louisville, Louisville, KY, USA; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    We examined the effects of reference tobacco preparations on DNA damage in human oral cavity cells. The oral squamous cell carcinoma cell line (101A), normal human gingival epithelial cells (HGEC), and human gingival fibroblasts (HGF) were treated...
  8. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 62

    The quantitative estimation of toxicant dose to cigarette smokers

    ST. CHARLES F.K.(1); MCAUGHEY J.(2); SHEPPERD J.(2)
    (1) St. Charles Consultancy, Winston Salem, NC, USA; (2) British American Tobacco (Investments) Limited, Southampton, UK
    For the risk assessment of cigarette smoke, a reliable estimate of the mass of chemical compounds retained in the body would be beneficial. Filter studies provide estimates of mouth exposure to compounds in cigarette smoke, but do not account for...
  9. TSRC, Tob. Sci. Res. Conf., 2011, 65, abstr. 30

    Microarray-based gene expression profiles of oral cavity cells exposed to different tobacco preparations.

    ZACHARIAS W.(1); HONG G.(1); PRASAD G.L.(2)
    (1) Dept. of Medicine, J.G. BROWN Cancer Center, Univ. of Louisville, Louisville, KY; (2) RJ Reynolds Tobacco Co., Winston-Salem, NC, USA
    Global gene expression profiles were determined for a panel of oral cavity cells in response to treatment by different tobacco preparations. Two human oral squamous cell carcinoma cell lines (101A, 101B) and normal gingival epithelial cells (HGEC)...