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  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 018

    Development of a small airway lung model using microfluidic lung-on-a-chip device

    MAKENA P.(1); PRASAD G.L.(1); GORDON D.(2); HAITHCOCK D.(2); PRABHAKARPANDIAN B.(2); PANT K.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) SynVivo Inc., Huntsville, AL, USA
    Current in vitro models of small airway lung, which have primarily been developed on a transwell membrane with epithelial cells cultured at air liquid interface (ALI), lack certain elements of the in vivo physiology such as fluidic shear and endothelial ...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 019

    Microfluidic small airway lung model for toxicity screening of tobacco products

    MAKENA P.(1); PRASAD G.L.(1); GORDON D.(2); HAITHCOCK D.(2); PRABHAKARPANDIAN B.(2); PANT K.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) SynVivo Inc., Huntsville, AL, USA
    Physiologically relevant in vitro lung models are valuable tools to accurately assess the cytotoxicity of inhaled toxicants. Epithelial cells cultured in transwells do not accurately represent the cellular architecture, physiology, and fluidic shear ...