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3 results

  1. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 057

    AKR1C1 as a biomarker for differentiating the biological effects of combustible from non-combustible tobacco products

    TRAN Q.T.(1); WOO S.(2); HENDERSON D.(2); GAO H.(3); ZACHARIAS W.(3); LIU G.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Axio Research, Seattle, WA, USA; (3) University of Louisville School of Medicine, Louisville, KY, USA
    Smoking has been established as a major risk factor for developing oral squamous cell carcinoma (OSCC), but less attention has been paid to the effects of smokeless tobacco products. Our objective is to identify potential biomarkers to distinguish the ...
  2. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 30

    Combusted, but not smokeless tobacco product preparations, cause DNA damage in human oral cavity cells

    ZACHARIAS W.(1); HONG GAO(1); PRASAD G.L.(2)
    (1) Brown Cancer Center, Univ. of Louisville, Louisville, KY, USA; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    We examined the effects of reference tobacco preparations on DNA damage in human oral cavity cells. The oral squamous cell carcinoma cell line (101A), normal human gingival epithelial cells (HGEC), and human gingival fibroblasts (HGF) were treated with ...
  3. TSRC, Tob. Sci. Res. Conf., 2011, 65, abstr. 30

    Microarray-based gene expression profiles of oral cavity cells exposed to different tobacco preparations.

    ZACHARIAS W.(1); HONG G.(1); PRASAD G.L.(2)
    (1) Dept. of Medicine, J.G. BROWN Cancer Center, Univ. of Louisville, Louisville, KY; (2) RJ Reynolds Tobacco Co., Winston-Salem, NC, USA
    Global gene expression profiles were determined for a panel of oral cavity cells in response to treatment by different tobacco preparations. Two human oral squamous cell carcinoma cell lines (101A, 101B) and normal gingival epithelial cells (HGEC) were ...