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351 results

  1. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 005

    Incorporating analytical variance into a comparative quantitative risk assessment (QRA) approach for tobacco products

    ANDERSON C.A.; HAASE V.; EHMAN K.D.; WIECINSKI P.N.; SMITH D.C.
    Altria Client Services, Richmond, VA, USA
    The US Food and Drug Administration (FDA) draft guidance for industry (2012) provides abbreviated lists of harmful and potentially harmful constituents (HPHCs) found in tobacco and cigarette smoke. As FDA considers the abbreviated HPHC list to be ...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 006 (also presented at CORESTA SSPT2019)

    In vitro testing of an ethanol collection method combining particulate and gas-vapor phase components: bacterial reversion mutation (Ames) assay

    BHARTI S.K.; SUKKA GANESH B.; SCIAN M.J.; GILLMAN I.G.
    Enthalpy Analytical, Henrico, VA, USA
    Health Canada (HC) guidelines (T-502) for the collection and testing of cigarette smoke are used frequently for in vitro testing. Although the guidelines allow the collection and testing of particulate phase (PP), gas-vapor (GVP) phase, and a combination ...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 007

    Conversion of a pharmaceutical salt-screening robot platform to an automated station for unattended weighing e-cigarettes and smoking machine filters

    COX J.A.; LU J.
    Sirius Automation Group, Buffalo Grove, IL, USA
    The authors will demonstrate how to adapt a standardized small footprint biotech laboratory robot originally designed for the screening of pharmaceutical salt & crystallization studies in advanced drug development for use in the high speed analytical ...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 008

    Workshop series to identify, discuss and develop recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    MOORE M.M.(1); CURREN R.(2)
    (1) Ramboll US Corporation, Little Rock, AR, USA; (2) Institute for In Vitro Sciences, Gaithersburg, MD, USA
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco and ...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 010

    Qualification of cell line A549 for the neutral red uptake (NRU) assay

    BRUCE S.; GARALA K.; SRINIVASAN D.; SPRINGER S.; DEY D.; CAMPASINO K.; KULKARNI R.
    MilliporeSigma (BioReliance® Toxicology Testing Services), Rockville, MD, USA
    As per 3R, in vitro cytotoxicity tests such as the Neutral Red Update (NRU) assay are routinely used as alternative toxicity tests to eliminate the use of animals for acute oral toxicity tests. The NRU assay is one of the most commonly used cytotoxicity ...
  6. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 011

    Comparison of vehicle controls for cell line A549 in the neutral red uptake (NRU) assay

    BRUCE S.; GARALA K.; SRINIVASAN D.; SPRINGER S.; DEY D.; CAMPASINO K.; KULKARNI R.
    MilliporeSigma (BioReliance® Toxicology Testing Services), Rockville, MD, USA
    To avoid and minimize acute oral toxicity tests on animals, in vitro cytotoxicity tests such the Neutral Red Uptake (NRU) assay are routinely performed. This assay does not have an OECD test guideline but the ICCVAM protocol and OECD guidance document 129 ...
  7. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 012

    Real-time monitoring of volatile organic compounds and aerosol in exhaled breath from inhalation of vapor products and combustible cigarettes

    O'REGAN D.C.(1); OZVALD A.M.(1); HEINE N.(1); GUTMANN R.(2); ROSENKRANZ B.(2)
    (1) JUUL Labs, San Francisco, CA, USA; (2) Ionicon, Innsbruck, Austria
    Exhaled breath (EB) analysis is an attractive methodology for clinical studies, due to its non-invasive nature. Analysis of Volatile Organic Compounds (VOCs) in exhaled breath may facilitate diagnosis of pathological conditions, including potential ...
  8. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 013 (also presented at CORESTA SSPT2019)

    Simultaneous determination analysis of glycerol, proplylene glycol, nicotine, menthol and water by discharge ionization detector on gas chromatography

    SHIMAZU A.; OMORI F.
    Japan Tobacco Inc., Tokyo, Japan
    Several analytical methods for determination of Glycerol (G), Propylene Glycol (PG), Nicotine, Menthol and Water in the aerosol of both e-cigarettes and tobacco vapor products were reported in the past few years. In the methods, those five components were ...