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294 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 005

    Effect of the addition of SBA-15 in the pyrolysis of a reference tobacco under inert and oxidizing atmosphere

    CALABUIG E.; MARCILLA A.; BELTRÁN M.I.
    University of Alicante, San Vicente del Raspeig, Spain
    The composition of evolved products from slow pyrolysis under inert and oxidizing atmospheres of a reference tobacco 3R4F from the Reference Cigarette Program of the College of Agriculture of the University of Kentucky and a mixture of the reference ...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 006

    Qualitative assessment of flavor ingredients in market electronic nicotine delivery systems

    HUDSON A.G.(1); CULBERT C.G.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) RAI Services Company, Winston-Salem, NC, USA
    As the use of electronic nicotine delivery systems (ENDS) grows, it may be useful to understand the types of flavor compounds that are being added as ingredients to the ENDS currently available on the market. A qualitative analysis of flavor compounds was ...
  3. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 009 (also presented at CORESTA 2018)

    Toxicological assessment of e-liquid formulations using in vitro genotoxicity and cytotoxicity assays

    COFFA B.G.; DOSHI U.; ZHANG Jingjie; McKINNEY W.J.; LEE K.M.
    Altria Client Services LLC, Richmond, VA, USA
    In the Electronic Nicotine Delivery Systems (ENDS) Premarket Tobacco Application (PMTA; 2016) Draft Guidance, the FDA recommends a full assessment of the toxicological profile associated with new tobacco products, using in vitro toxicology (e.g., ...
  4. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 010 (also presented at CORESTA 2018)

    Evaluation of novel, oral tobacco-derived nicotine products for HPHCs

    DANIELSON T.L.; McFARLANE C.B.; BROWN A.P.; JIN Xiaohong; WILKINSON C.T.; PITHAWALLA Y.B.; McKINNEY W.J. Jr.
    Altria Client Services LLC, Richmond, VA, USA
    VERVE® Discs and Chews are oral, non-dissolvable, tobacco-derived nicotine products. In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule to deem e-cigarettes, cigars and all other tobacco products, including VERVE® to be subject ...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 011 (also presented at CORESTA 2018)

    Quantification of nicotine related impurities in novel, oral tobacco-derived nicotine products

    DANIELSON T.L.; McFARLANE C.B.; NOE M.R.; PITHAWALLA Y.B.; McKINNEY W.J. Jr.
    Altria Client Services LLC, Richmond, VA, USA
    VERVE® Discs and Chews are oral, non-dissolvable, tobacco-derived nicotine products. In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule to deem e-cigarettes, cigars and all other tobacco products, such as VERVE®, to be subject to ...
  6. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 012

    Equivalence testing in demonstrating substantial equivalence for new tobacco products

    FROST-PINEDA K.(1); CAMPBELL L.R.(1); POLSTER M.(2); CURTIN G.M.(1)
    (1) RAI Services Company, Winston Salem, NC, USA; (2) Naxion, Philadelphia, PA, USA
    Under Section 905j of the Tobacco Control Act, manufacturers must submit reports to the FDA to demonstrate that a new tobacco product is substantially equivalent (SE) to a “predicate product.” Demonstrating equivalence with traditional statistical ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 013

    Method development for pH analysis of ends aerosol and e-liquid

    HEFNER T.(1); ST. CHARLES F.K.(2); ANDERSON J.(3)
    (1) R.J. Reynolds Tobacco Company, Winston Salem, NC, USA; (2) St.Charles Consultancy, Winston Salem, NC, USA; (3) Eurofins Lancaster Labs, Winston Salem, NC, USA
    E-liquids are hygroscopic, non-aqueous liquids containing a small amount of water (~3-15%). When the pH of a non-aqueous liquid is measured using conventional methods and calibration buffers, the value can only be regarded as an "apparent pH". ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 014 (also presented at CORESTA 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 1. Mouse lymphoma assay

    LEVERETTE R.(1); BOMBICK B.(1); FOWLER K.(1); BREHENY D.(2); GACA M.(2); THORNE D.(2); CLEMENTS J.(3); LLOYD M.(3); McENANEY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) British American Tobacco (Investments) Ltd., Southampton, UK; (3) Covance Laboratories Ltd, Harrogate, UK
    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from different tobacco and nicotine delivery products was assessed against ...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 015 (also presented at CORESTA 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 2. In vitro micronucleus assay

    LEVERETTE R.(1); BOMBICK B.(1); FOWLER K.(1); BREHENY D.(2); GACA M.(2); THORNE D.(2); CLEMENTS J.(3); McENANEY S.(3); WHITWELL J.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) British American Tobacco (Investments) Ltd., Southampton, UK; (3) Covance Laboratories Ltd, Harrogate, UK
    In vitro studies have been widely used to support toxicological evaluations of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F ...