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1004 results

  1. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 001 (Symposium)

    Is civil dialogue and engagement between diverse stakeholders with respect to tobacco harm reduction feasible? A review of the past, present and future

    BALLIN S.D.
    Health Policy Consultant, Washington, DC, USA
    With a billion smokers in the world and an annual toll of 7 million premature deaths, more can be done to significantly reduce or even eliminate the use of combustible products. Part of that effort involves the development of science- based consumer ...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 005

    Incorporating analytical variance into a comparative quantitative risk assessment (QRA) approach for tobacco products

    ANDERSON C.A.; HAASE V.; EHMAN K.D.; WIECINSKI P.N.; SMITH D.C.
    Altria Client Services, Richmond, VA, USA
    The US Food and Drug Administration (FDA) draft guidance for industry (2012) provides abbreviated lists of harmful and potentially harmful constituents (HPHCs) found in tobacco and cigarette smoke. As FDA considers the abbreviated HPHC list to be ...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 006 (also presented at CORESTA SSPT2019)

    In vitro testing of an ethanol collection method combining particulate and gas-vapor phase components: bacterial reversion mutation (Ames) assay

    BHARTI S.K.; SUKKA GANESH B.; SCIAN M.J.; GILLMAN I.G.
    Enthalpy Analytical, Henrico, VA, USA
    Health Canada (HC) guidelines (T-502) for the collection and testing of cigarette smoke are used frequently for in vitro testing. Although the guidelines allow the collection and testing of particulate phase (PP), gas-vapor (GVP) phase, and a combination ...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 007

    Conversion of a pharmaceutical salt-screening robot platform to an automated station for unattended weighing e-cigarettes and smoking machine filters

    COX J.A.; LU J.
    Sirius Automation Group, Buffalo Grove, IL, USA
    The authors will demonstrate how to adapt a standardized small footprint biotech laboratory robot originally designed for the screening of pharmaceutical salt & crystallization studies in advanced drug development for use in the high speed analytical ...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 008

    Workshop series to identify, discuss and develop recommendations for the optimal generation and use of in vitro genotoxicity assay data for tobacco and nicotine products

    MOORE M.M.(1); CURREN R.(2)
    (1) Ramboll US Corporation, Little Rock, AR, USA; (2) Institute for In Vitro Sciences, Gaithersburg, MD, USA
    The Institute for In Vitro Sciences is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro regulatory genotoxicity assay data within and across tobacco and ...
  6. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 010

    Qualification of cell line A549 for the neutral red uptake (NRU) assay

    BRUCE S.; GARALA K.; SRINIVASAN D.; SPRINGER S.; DEY D.; CAMPASINO K.; KULKARNI R.
    MilliporeSigma (BioReliance® Toxicology Testing Services), Rockville, MD, USA
    As per 3R, in vitro cytotoxicity tests such as the Neutral Red Update (NRU) assay are routinely used as alternative toxicity tests to eliminate the use of animals for acute oral toxicity tests. The NRU assay is one of the most commonly used cytotoxicity ...