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62 results

  1. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 02

    Tools for the prioritisation of tobacco smoke toxicants: an overview.

    CUNNINGHAM F.; FIEBELKORN S.; DILLON D.; MEREDITH C.
    British American Tobacco, Group Research & Development, Southampton, UK
    A scientific, evidence-based risk assessment method to assess potential health risks of individual tobacco smoke toxicants, reflecting the range of yields and human characteristics related to exposure, is a beneficial tool for tobacco product regulation ...
  2. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 04

    Past, present and future approaches for reducing cadmium content in tobacco leaves

    MANOHAR M.(1,2); SHIGAKI T.(3); SHIGAKI L.(3);HIRSCHI K.D.(1,2)
    (1) United States Department of Agriculture/Agricultural Research Service Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA; (2) Vegetable and Fruit Improvement Center, Texas A&M University, College Station, TX, USA; (3) Papua New Guinea National Agricultural Research Institute, Papua, New Guinea
    Contamination of soils by heavy metals such as cadmium is of great concern for global agricultural practices and human health. To overcome the toxic effects of heavy metals, plants have evolved various mechanisms such as reduced intake of toxic metals, ...
  3. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 07

    Complete artificial saliva alters expression of proinflamma-tory cytokines in human dermal fibroblasts

    MALPASS G.E.(1); ARIMILLI S.(1); PRASAD G.L.(2); HOWLETT A.C.(1)
    (1) Wake Forest University Health Sciences, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    Complete artificial saliva (CAS) is a saliva substitute often used as a vehicle for test articles, including, smokeless tobacco. We discovered, using polymerase chain reaction gene expression array analyses, that CAS increased gene expression for certain ...
  4. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 08

    Method development for enumeration of endothelial progenitor cells (EPCs)

    PRASAD G.L.(1); ARIMILLI S.(2); JONES B.A.(1); FEARON I.(3)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) Wake Forest University Baptist Health, Winston-Salem, NC, USA; (3) British American Tobacco GR&D, Southampton, UK
    Endothelial progenitor cells (EPCs) are a type of white blood cells present in circulation at low numbers and are hypothesized to play a role in the protection and repair of the of cardiovascular system. EPCs, characterized as cells expressing the surface ...
  5. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 10

    Dosimetric assessment of whole smoke particulate deposition in vitro: a proposed common approach using quartz crystal microbalance technology.

    ADAMSON J.; THORNE D.; DALRYMPLE A.; MEREDITH C.; DILLON D.
    British American Tobacco, Southampton, UK
    There are a number of different smoking machines and exposure chamber combinations used by our industry to assess the toxicological impact of cigarette smoke in vitro. The amount of smoke delivered to cells within an in vitro exposure system can be ...
  6. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 11

    Limitation of standard deviation to express variability.

    TEILLET B.(1); VERRON T.(1); CAHOURS X.(1); COLARD S.(2); PURKIS S.(2)
    (1) SEITA Imperial Tobacco Group, Fleury-les-Aubrais, France; (2) Imperial Tobacco Limited, Bristol, UK
    In the framework of growing regulations regarding tobacco products, increased requirements are observed for reporting of analytical figures (e.g. FDA). This paper deals with the reporting of data variability in this context. The objective was to evaluate ...