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95 results

  1. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 002 (Symposium)

    The role of industry in engaging with industry to develop regulatory-approved methods for tobacco and nicotine product assessment

    PROCTOR C.J.; FEARON I.M.; MARINER D.C.; WRIGHT C.; MURPHY J.
    British American Tobacco (Investments) Limited, Southampton, UK
    Industry consensus methods for product assessment are commonplace across many industrial sectors and often form the basis of regulatory approaches. In the pharmaceutical industry for example, the foundations for the assessment of the safety, quality and ...
  2. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 005 (also presented at CORESTA SSPT2017)

    Use of formalin in e-vapor products to monitor formaldehyde delivery

    SPANGLER K.; WILKINSON J.; MELVIN M.S.; MILLER J.H. IV; KARLES G.D.
    Altria Client Services, Richmond, VA, USA
    Guidance provided by the FDA (May of 2016) for Premarket Tobacco Product Applications for Electronic Nicotine Delivery Systems proposes full chemical characterization of the e-cigarette aerosol. One class of compounds the FDA recommends to be reported in ...
  3. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 007

    Neutral red uptake cytotoxicity assay in A549 cells under different culture conditions

    COFFA B.G.(1); DOSHI U.(1); ZHANG Jingjie(1); McKINNEY W.J.(1); LEE K.M.(1); DESAI P.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) Enthalpy Analytical, Richmond, VA, USA
    The OECD guideline (TG129) recommends mouse fibroblasts (3T3) & normal human epidermal keratinocytes (NHK) for performing in vitro cytotoxicity assays but also mentions limitations of these cells, such as having little to no metabolic capacity or ...
  4. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 008

    Are available test methods for the determination of carbonyls in mainstream cigarette smoke fit for the analysis of cigars?

    BALLENTINE R.M.; AVERY K.C.; MELVIN M.S.; SMITH J.H.; WAGNER K.A.
    Altria Client Services, Richmond, VA, USA
    In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule to deem cigars to be subject to the Federal Food, Drug, and Cosmetic Act, as amended by the Family Smoking Prevention and Tobacco Control Act. As part of this regulation, the FDA ...
  5. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 009 (also presented at CORESTA SSPT2017)

    The challenges of machine smoking the diverse cigar product category

    BLAKE T.L.(1); BALLENTINE R.M.(1); AVERY K.C.(1); BROWN A.P.(1); WAGNER K.A.(1); CARPENTER M.J.(2); STUTT K.L.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) Eurofins Lancaster Laboratories, Richmond, VA, USA
    In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule to deem cigars to be subject to the Federal Food, Drug, and Cosmetic Act (the FD&C Act), as amended by the Family Smoking Prevention and Tobacco Control Act (Tobacco Control ...
  6. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 010 (also presented at CORESTA SSPT2017)

    Differences in plasma nicotine pharmacokinetic profiles for various e-vapor products used by adult smokers under ad-libitum vs. controlled use conditions

    LIU Jianmin; LIANG Qiwei; GOGOVA M.; ZHAO Yuxi; SARKAR M.
    Altria Client Services, Richmond, VA, USA
    Plasma nicotine pharmacokinetic (PK) profiles are often used to characterize nicotine exposure from e-vapor products (EVP). The purpose of this analysis was to determine whether PK profiles are different when adult smokers (AS) use EVPs under ad libitum ...