1. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPT 22

    Development of biomarkers of effect from chronic tobacco usage. Part 1: Study design and biomarkers of exposure

    JONES B.A.; CHEN P.; SCHMIDT E.; PRASAD G.L.
    R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA
    To assess the effects of chronic exposure to combustible and non-combustible tobacco product use, a single site, cross-sectional clinical study was conducted. Three cohorts of healthy males (40/cohort, 35-60 years) were enrolled: long-term smokers...
  2. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPT 23

    Development of biomarkers of effect from chronic tobacco usage. Part 2: Inflammation and oxidative stress

    PRASAD G.L.; JONES B.A.; CHEN P.; SCHMIDT E.
    R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA
    In a recent clinical study, we investigated the long-term effects of smoking and moist snuff consumption using a panel of biomarkers of effect (BioEff) indicative of inflammation, oxidative stress and lipid metabolism. In this, cross-sectional study,...
  3. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPT 24

    Development of biomarkers of effect from chronic tobacco usage. Part 3: Potential metabolomics biomarkers of tobacco effect

    PRASAD G.L.(1); CHEN P.(1); JONES B.A.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA; (2) Metabolon, Durham, NC, USA
    Epidemiological data indicate that consumption of moist snuff is associated with reduced harm relative to cigarette smoking. However, a need exists for interim biomarkers of effect (BioEff) that would be useful to assess the health effects of...
  4. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPTPOST 36

    Development of biomarkers of effect from chronic tobacco usage.Part 4: Metabolomic profiles from cigarette smokers and moist snuff consumers

    PRASAD G.L.(1); CHEN P.(1); JONES B.A.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA; (2) Metabolon, Durham, NC, USA
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term...
  5. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 23

    Development of biomarkers of effect from chronic tobacco usage: Part 4. Metabolomic profiles from cigarette smokers and moist snuff consumers

    PRASAD G.L.(1); CHEN P.(1); JONES B.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) Metabolon, Inc., Durham, NC, USA
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term...
  6. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 24

    Development of biomarkers of effect from chronic tobacco usage: Part 1. Study design and biomarkers of exposure

    JONES B.; CHEN P.; SCHMIDT E.; PRASAD G. L.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    To assess the effects of chronic exposure to combustible and noncombustible tobacco product use, a single site, cross-sectional clinical study was conducted. Three cohorts of healthy males (40/cohort, 35-60 years) were enrolled: long-term smokers and...
  7. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 25

    Development of biomarkers of effect from chronic tobacco usage: Part 2. Inflammation and oxidative stress

    PRASAD G.L.;CHEN P.; SCHMIDT E.; JONES B.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    In a recent clinical study, we investigated the long-term effects of smoking and moist snuff consumption using a panel of biomarkers of effect (BioEff) indicative of inflammation, oxidative stress and lipid metabolism. In this, cross-sectional study,...
  8. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 26

    Development of biomarkers of effect from chronic tobacco usage: Part 3. Potential metabolomics biomarkers of tobacco effect.

    PRASAD G. L.(1); CHEN P.(1); JONES B.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) Metabolon, Inc., Durham, NC, USA
    Epidemiological data indicate that consumption of moist snuff is associated with reduced harm relative to cigarette smoking. However, a need exists for interim biomarkers of effect (BioEff) that would be useful to assess the health effects of...