Bull. Spec. CORESTA Congress, Brighton, 1998, p. 169, ST21
The inhibitory effect of cotinine or cigarette smoke on the formation of O<sup>6</sup>-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, induces lung adenomas in A/J mice following a single intraperitoneal (i.p.) injection. NNK-induced lung tumorigenesis is thought to involve O6-methylguanine (O6MeG)...