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88 results

  1. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 01

    Integrating chemical, toxicological and clinical research to assess the potential of reducing health risks associated with cigarette smoking through toxicant regulation

    PROCTOR C.; SHEPPERD C.; McADAM K.; ELDRIDGE A.; MEREDITH C.
    British American Tobacco, Group Research and Development Centre, Regents Park Road, Southampton, UK
    The concept of a risk continuum for tobacco and nicotine products has been proposed that represents the likely association of different categories of product with toxicant exposure and possibly risk. At one end are cigarettes, deemed the most risky,...
  2. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 03

    Molecular biology-based approaches for facilitating compliance of future tobacco products in an FDA regulatory environment

    DEWEY R.E.; LEWIS R.S.
    North Carolina State University, Raleigh, North Carolina, USA
    Passed in 2009, the Family Smoking Prevention and Tobacco Control Act granted the U.S. Food and Drug Administration (FDA) the authority to regulate tobacco products. Among the powers given the FDA in this landmark legislation was the authority to...
  3. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 05

    The use of precision-cut lung slices to assess inflammation, parenchymal damage, and collagen deposition: three markers of tobacco exposure-induced pulmonary toxicity

    BEHRSING H.P.
    Institute for In Vitro Sciences, Inc., Gaithersburg, Maryland, USA
    The Family Smoking Prevention and Tobacco Control Act (TCA) gives the Food and Drug Administration (FDA) broad authority to regulate tobacco products. The FDA-Center for Tobacco Products (CTP) calls for several research priority areas, including in...
  4. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 07

    Retrospective analysis of data from cigarette smoke mouth level exposure (MLE) studies

    BOWMAN S.A.; CARAWAU J.; CHEN P.; NELSON P.R.
    R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA
    Over the past eight years, R.J. Reynolds Tobacco Company conducted a series of cigarette smoke mouth-level exposure (MLE) studies. In those studies, used cigarette filters were analyzed to determine per cigarette and daily MLE to “tar” and nicotine....
  5. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 08

    Evaluation of an online, puff-by-puff method for the determination of nitric oxide, nitrogen dioxide, and total mono-nitrogen oxides in fresh mainstream smoke

    GILLMAN I.G.(1); BLOMBERG J.D.(1); TINDALL I.F.(2); CRUMPLER L.A.(2); VINCENT J.H.(2)
    (1) Enthalpy Analytical Inc., Durham, North Carolina, USA; (2) Cerulean, Milton Keynes, UK
    The amount of nitric oxide (NO), nitrogen dioxide (NO2) and total mono-nitrogen oxides (NOx) in mainstream smoke is of regulatory concern, but to date few reliable methods exist for the accurate measurement of these compounds. NO can be difficult to...