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5 results

  1. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 49

    Use of chiroptical spectroscopy to determine the ionisation status of (S)-nicotine in electronic cigarette formulations and snus

    CLAYTON P.M.; VAS C.A.; McADAM K.G.
    British American Tobacco, Group R&D, Southampton, U.K.
    In the vicinity of neutral pH, nicotine is equilibrated between unprotonated and monoprotonated states. The equilibrium is best described by the acid dissociation constant (Ka) and its logarithmic function known as pKa which in non-aqueous solution...
  2. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 57

    Results of the 2013 CORESTA Part-Filter Method Ring Trial and comparison with the 2012 Ring Trial

    CLAYTON P.M.(1); NOTHER K.(1); VERRON T.(2); JULIEN R.(2)
    British American Tobacco, Group R&D, Southampton, U.K.
    A ring trial of the Part-Filter Method, under the auspices of the CORESTA Smoking Behaviour Sub-Group, involving laboratories from the tobacco industry and the contract sector was concluded and the results presented to the Sub-Group in October 2013....
  3. CORESTA Meeting, Smoke Science/Product Technology, 2011, Graz, ST 16

    Spectroscopic investigations into the acid-base properties of nicotine at different temperatures

    CLAYTON P.M.(1); VAS C.(1); BUI T.T.T.(2); DRAKE A.F.(2); McADAM K.G.(1)
    (1) British American Tobacco, Group R&D, Southampton, UK; (2) Applied Photophysics Limited, Leatherhead, UK
    The nicotine molecule contains two separate and distinct ionisable moieties both centred on nitrogen atoms. In aqueous solution nicotine can exist in three states of ionisation: under acidic conditions (low pH) it will be present predominantly as the...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2011, Graz, ST 28

    Results of the 2010 CORESTA Part Filter Method Ring Trial

    CLAYTON P.M.(1); VERRON T.(2); PRASAD S.K.(1)
    (1) British American Tobacco, Group R&D, Southampton, UK; (2) SEITA Imperial Tobacco Group, Fleury-les-Aubrais, France
    The Part Filter Method (PFM) is used to estimate smokers' mouth-level exposure to nicotine and tar. Previously in 2006 the CORESTA Smoking Behaviour Sub-Group commissioned a ring trial of the PFM in which participating laboratories completed the...
  5. CORESTA Congress, Edinburgh, 2010, SS 10

    The development and application of a method for the estimation of mouth level exposure (MLE) to four tobacco specific nitrosamines

    CLAYTON P.M.; PRASAD K.; SISODIYA A.
    British American Tobacco, Group R&D, Southampton, UK
    Tobacco specific nitrosamines (TSNA) in cigarette smoke are an important class of toxicants. Therefore the quantification of TSNA via spent filters from smokers is a valuable addition to the filter analysis method. Previous research has shown that...