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17 results

  1. TSRC, Tob. Sci. Res. Conf., 2011, 65, abstr. 20

    An in vitro comparative study of [14c]-eugenol and [14c]-methyleugenol activation and detoxification kinetics in human, mouse, and rat liver fractions.

    MINET E.(1); GENTILE D.(2); MEREDITH C.(1); MASSEY E.D.(1)
    (1) British American Tobacco, Group R&D, Southampton, UK; (2) Charles River Laboratories, Edinburgh, UK
    Introduction - Eugenol is a natural alkenylbenzene compound used in a variety of consumer products including Kretek cigarettes. There is limited evidence for the carcinogenicity of eugenol to experimental animals. However, in vitro tests for the...
  2. CORESTA Meeting, Smoke Science/Product Technology, Stratford-upon-Avon, 2005, IG 01,CORESTA Meeting, Agronomy/Phytopathology, Santa Cruz do Sul, 2005, IG 02

    A new system for measuring the toxicity of mainstream cigarette smoke

    GAҪA M.D.; PHILLIPS J.; THORNE D.; LOWE F.; WILSON J.; MCEWAN M.; RICHTER A.; MASSEY E.D.
    British American Tobacco, Group R&D, Southampton, UK
    Cigarette smoke is a complex mixture of thousands of chemicals distributed between the particulate or 'tar' phase and the vapour phase which constitute 5% and 95% of whole smoke by weight, respectively. Historically, the in vitro toxicological...
  3. CORESTA Meeting, Smoke Science/Product Technology, Stratford-upon-Avon, 2005, SSPT 04

    The effect of cigarette design variables on assays of interest to the Tobacco Industry: - 4) in vitro genotoxic activity of mainstream cigarette smoke

    KALIRAI K.; WHITTLE J.; COWIN R.; CLACK A.; LANGFORD R.; MASSEY E.D.
    British American Tobacco, Group R&D, Southampton, UK
    The modification of cigarette design parameters in a statistically based central composite experimental design framework incorporating paper permeability, filter pressure drop, filter ventilation and tobacco blend and the resulting effects in terms...
  4. CORESTA Meeting, Smoke Science/Product Technology, Stratford-upon-Avon, 2005, SSPT 21

    A toxicogenomic study of primary human lung epithelial cells exposed to whole cigarette smoke

    RICHTER A.; MAUNDERS H.; MASSEY E.D.
    British American Tobacco, Group R&D, Southampton, UK
    Cigarette smoking is strongly associated with the development of lung cancer and chronic obstructive pulmonary disease. In order to investigate the potential mechanisms of smoke toxicity we have performed a transcriptomics study of the effects of...
  5. CORESTA Meeting, Smoke Science/Product Technology, Stratford-upon-Avon, 2005, SSPT 22

    Development of an in vitro assay for the investigation of oxidative DNA damage induced by cigarette smoke

    McEWAN M.; THORNE D.; LOWE F.; WILSON J.; PHILLIPS J.; RICHTER A.; MASSEY E.D.
    British American Tobacco, Group R&D, Southampton, UK
    Cigarette smoke contains a mixture of more than 4,000 chemicals, some of which may be involved in oxidative damage of biomolecules, including DNA (Pourcelot et al. 1999). As a method of investigating these potential effects on DNA, the modified in...