Cooperation Centre for Scientific Research Relative to Tobacco
Centre de Coopération pour les Recherches Scientifiques Relatives au Tabac

Gene expression profiling is considered as a promising tool that may identify more sensitive, mechanism-based biomarkers. Such an experimental approach should provide a better understanding of the impact of chemical compounds on the intracellular...

The Electronic Nose (E-Nose) response has been optimized by an experimental design aimed at defining a standard method to analyze blend tobacco. A possible application of this apparatus is to use it as an "on line" quality control tool in...

The ISO or FTC smoking conditions (35 mL - 2 s puffs, 1 puff per minute) have been more and more criticized during the last decade, especially because they would not reflect the human smoking behaviour. Their main objective was not to predict the...

In order to mimic the aromatic modifications occurring in tobaccos during combustion, a preparation method, applied on tobacco samples, is carried out. Tobacco samples are heated under pressure at 170 °C during 2 hours. In such conditions, Maillard...

In order to increase our efficiency in assessing the cigarette smoke's toxicity, we developed fast cell-free methods allowing a first selection before in vitro classical testings. We will here describe a cell-free method, based on the depletion of...

The ß-carboline compounds, harman (1-methyl-9H-pyrido[3,4-b]indole) and norharman (9H-pyrido[3,4-b]indole), occur in medicinal plants and in variety of food, alcoholic beverages, industrial waste and tobacco smoke. These compounds are synthesized by...

Having a tool that can predict the Hoffmann analytes has become necessary, not only because of regulations, but also as a reference for the chemical composition of smoke for the Potential Reduced Exposure Products (PREPs). The work presented in...

Chemical analyses of special analytes (e.g. TSNAs) or biological tests on the smoke are rather sophisticated and time consuming technologies. Giving estimates based on fast analyses would enable the blenders to have a tool allowing them to reduce...

Cigarette smoke (CS) contains numerous compounds, among which free radicals and aldehydes that can potentially react with low molecular antioxidants, such as glutathione (GSH). Thus, the GSH depletion measurement can be used to assess the oxidative...

Group classification of tobacco blends is commonly performed using several different types of compositional data including tobacco compounds, additive or process components. But all of these wet chemistry methods are relatively time-consuming. A need...