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12 results

  1. CORESTA Meeting, Smoke Science/Product Technology, Jeju, 2007, IG 02, Agronomy/Phytopathology, Krakow, 2007, IG 02

    An effective product evaluation strategy for PREP cigarettes

    DOOLITTLE D.J.; COOK C.J.; WILSON C.L.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    Cigarette smoking has been shown to substantially increase the risk of a number of diseases; including lung cancer, pulmonary disease and heart disease. There is agreement among many stakeholders that the development of potentially reduced exposure...
  2. CORESTA Meeting, Smoke Science/Product Technology, Stratford-upon-Avon, 2005, SSPT 23

    Gene expression profiles in normal human bronchial epithelial (NHBE) cells following exposure to smoke condensate from cigarettes that burn or primarily heat tobacco

    DOOLITTLE D.J.; FIELDS W.R.; BOMBICK B.R.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    Cigarette smoke is a complex chemical mixture that includes compounds associated with oxidative stress, inflammation and DNA damage. Our laboratory previously reported that smoke condensate from cigarettes that primarily heat tobacco produce less...
  3. CORESTA Congress, Kyoto, 2004, SS 01

    Individual variations in cigarette mainstream smoke biomarkers of exposure

    DOOLITTLE D.J.; SMITH C.J.; MORTON M.J.; BOMBICK D.W.; BROWN B.G.; HEAVNER D.L.; MORGAN W.T.; OGDEN M.W.; ROBINSON J.H.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    Biomarkers of tobacco smoke exposure were measured in urine and buccal cells from 56 smokers of full-flavor low 'tar' (FFLT) cigarettes to evaluate the degree of individual variation. Biomarkers were measured while each individual smoked their usual...
  4. CORESTA Congress, Kyoto, 2004, SS 13

    Gene expression in normal human bronchial epithelial (NHBE) cells following in vitro exposure to cigarette smoke condensate

    DOOLITTLE D.J.; FIELDS W.R.; OGDEN M.W.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    Oxidative stress, DNA damage, and inflammation resulting from chemical exposure may alter cell cycle regulation, which is believed to an important biological event in the carcinogenic process. Cigarettes that burn tobacco produce a complex mixture of...
  5. CORESTA Congress, New Orleans, 2002, STPOST 05

    Changes in free levels of oxidative DNA damage/repair products in the alveolar fluid of smokers after switching to Eclipse, a cigarette that primarily heats rather than burns tobacco

    DOOLITTLE D.J.; BROWN B.; MATSON W.; BOGDANOV M.; RENNARD S.; ROMBERGER D.; MANOUILOVA L.; XIANGDE L.
    R.J. Reynolds Tobacco Company, Winston Salem, NC, USA
    Oxidative DNA damage has been implicated in aging, carcinogenesis, heart disease, and neurodegenerative diseases. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a principal stable marker of hydroxyl radical damage to DNA. Tobacco smoking has been shown to...
  6. CORESTA Meeting, Smoke/Technology, Xian, 2001, ST 04

    The use of in vitro short term tests to evaluate progress toward reducing the toxicity of cigarette smoke

    DOOLITTLE D.J.; BOMBICK D.W.; BOMBICK B.R.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    A number of tobacco companies are actively pursuing the development of cigarettes with the potential to reduce the risks associated with smoking. Despite decades of debate, the scientific community still lacks a consensus concerning what cigarette...
  7. Bull. Spec. CORESTA Congress, Lisbon, 2000, p. 168, ST23

    Biological studies on smoke condensates from cigarettes made with low nitrosamine flue-cured tobacco

    DOOLITTLE D.J.; AVALOS J.T.; BOMBICK B.R.; PUTNAM K.P.; BOMBICK D.W.; NESTOR T.B.; GENTRY J.S.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    R. J. Reynolds Tobacco Company recently developed a process for flue-curing tobacco that results in substantially lower concentrations of tobacco-specific nitrosamines. The technology is based on the use of heat exchangers instead of direct-fired...
  8. Bull. Spec. CORESTA Congress, Brighton, 1998, p. 169, ST21

    The inhibitory effect of cotinine or cigarette smoke on the formation of O<sup>6</sup>-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

    DOOLITTLE D.J.; BROWN B.G.; AYRES P.H.; CHANG C.J.G.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, induces lung adenomas in A/J mice following a single intraperitoneal (i.p.) injection. NNK-induced lung tumorigenesis is thought to involve O6-methylguanine (O6MeG)...