Search Results

8 results

  1. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 038

    Optimization and comparison of 2,4-dinitrophenylhydrazine (DNPH) derivatization conditions for the determination of carbonyl compounds

    JEONG L.(1); MILLER, J.H., IV(2); SHAH N.(2)
    (1) Eurofins Lancaster Laboratories, Richmond, VA, USA; (2) Altria Client Services, Richmond, VA, USA
    FDA’s Premarket Tobacco Product Application (PMTA) draft guidance for Electronic Nicotine Delivery Systems (ENDS) recommends analysis of four carbonyls in e-liquids and aerosols - Formaldehyde, Acetaldehyde, Acrolein and Crotonaldhyde. There are two...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 104

    Preclinical testing of flavors in e-vapor products - Part 2: Preparation and stability characterization of representative flavor mixtures

    SMITH C.R.(1); MILLER J.H. IV(1); SHAH N.(1); KUMAR A.(1); LEE K.M.(1); FRAUENDORFER F.(2); GUY P.(2); DIANA P.(2); GLABASNIA A.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) PMI R&D, Neuchâtel, Switzerland
    GLP guidelines require the characterization of test articles for preclinical biological studies to ensure the identity and composition are consistent from batch to batch and throughout the testing period. For e-vapor products, this would suggest that...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 44 (also presented at TSRC 2018)

    Non-targeted analysis using gas chromatography mass spectrometry to evaluate stability of e-vapor products

    SHAH N.; CROSSWHITE M.; NOE M.R.; SUAREZ C.; MILLER J.H.; PITHAWALLA Y.B.; GARDNER W.P.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In the newly regulated landscape of tobacco products there is an increasing need to fully characterize the chemical composition of aerosol in new products. Although aerosol from e-vapor products are considerably less complex than aerosols from...
  4. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 064 (also presented at CORESTA 2018)

    Non-targeted analysis using gas chromatography mass spectrometry to evaluate stability of e-vapor products

    CROSSWHITE M.; SHAH N.; NOE M.; SUAREZ C.; MILLER J.H. IV; PITHAWALLA Y.B.; GARDNER W.P.
    Altria Client Services LLC, Richmond, VA, USA
    In the newly regulated landscape of tobacco products there is an increasing need to fully characterize the chemical composition of aerosol in new products. Although aerosol from e-vapor products are considerably less complex than aerosols from...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 094

    Are available test methods for the determination of ammonia in mainstream cigarette smoke fit for the analysis of cigars? – Part 2

    PREPELITSKAYA Y.; MILLER J.H.; RUSYNIAK M.; HIGGINS F.S.; AVERY K.C.; CROSSWHITE M.; SPICER-GLAVE S.; SHAH N.
    Altria Client Services LLC, Richmond, VA, USA
    In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule deeming cigar products within scope of their regulatory authority. Under this regulation the FDA will require manufacturers to report the quantities of Harmful and...
  6. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 03

    Determination of tobacco specific nitrosamines (TSNAs) in tobacco and tobacco smoke by GC-MS/MS

    SHAH N.; SMITH T.; FLORA J.W.; MERUVA N.
    Altria Client Services Inc., Richmond, VA, U.S.A.
    NNN (N'-nitrosonornicotine), NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone), NAB (N'-nitrosoanabasine) and NAT (N'-nitrosoanatabine) are the most common tobacco specific nitrosamines (TSNAs) measured in tobacco and tobacco smoke. While CORESTA...
  7. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 09

    Improved method for determination of tobacco-specific nitrosamines (TSNAs) in tobacco and tobacco smoke by UPLC-MS/MS

    SHAH N.; FLORA J.W.; MERUVA N.
    Altria Client Services Inc., Richmond, VA, U.S.A.
    Tobacco-specific nitrosamines (TSNA) are harmful and potentially harmful constituents (HPHCs) found in tobacco products. In an effort to standardize quantitative analytical methods for TSNA analysis and reporting, CORESTA has published reference...
  8. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 10

    Determination of heterocyclic aromatic amines in cigarette smoke by UPLC-MS/MS

    SHAH N.; JIN C.; AVERY K.; FLORA J.W.; MERUVA N.
    Altria Client Services Inc., Richmond, VA, U.S.A.
    As stated in the Federal Register (Vol. 77, No. 64 / Tuesday, April 3, 2012) Docket No. FDA-2012-N-0143, Heterocyclic Aromatic Amines (HAAs) are included in the “Established List of the Chemicals and Chemical Compounds Identified by the United States...