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  1. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, NAM 00

    New Approach Methods (NAMs) Symposium-II: Applications in Tobacco Regulatory Sciences

    LEE K.M.(1); SIMMS L.(2)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Imperial Brands PLC, Bristol, U.K.
    New Approach Methods (NAMs) in toxicology refer generally to in vitro and in silico or computational methodologies that, without additional in vivo animal testing, could enable clinically relevant toxicological risk assessment. At CORESTA...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, NAM 03

    Exposure to fresh whole smoke and aerosols: standard and novel (3D) in vitro models

    POUR S.J.(1); SIMMS L.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Imperial Brands PLC, Bristol, U.K.
    New Approach Methods (NAMs) describe non-animal- based methodologies that enable more human relevant toxicological risk assessments. In this talk, regulatory in vitro toxicology assays (CORESTA battery) are refined for NGP (Next Generation Product)...
  4. CORESTA Congress, Online, 2022, Smoke Science/Product Technology Groups, ST 54

    Comparison of heated tobacco product aerosol to cigarette smoke in human bronchial epithelial tissues using high content screening

    TRELLES STICKEN E.(1); WIECZOREK R.(1); POUR S.J.(1); CHAPMAN F.(2); SIMMS L.(2); STEVENSON M.(2)
    (1) Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (2) Imperial Brands PLC, Bristol U.K.
    Laboratory studies have shown heated tobacco product (HTP) aerosols have substantially reduced numbers and levels of harmful and potentially harmful constituents (HPHCs) relative to combustible cigarette smoke. The biological impact of these aerosols...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 01

    The application of in vitro Toxicity Testing in 21 Century (TT21C) for next generation products

    SIMMS L.(1); TRELLES STICKEN E.(2)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The aim is to demonstrate the feasibility of TT21C in vitro methods as part of an overall assessment framework for next generation products (NGP). TT21C methodologies can be used to assess harm reduction potential of NGPs using human-derived...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 62

    Overview of in vitro methods used to assess e-cigarettes based on “Toxicity Testing in 21st Century” principles

    SIMMS L.(1); STEVENSON M.(1); CZEKALA L.(1); TSCHIERSKE N.(1); WALELE T.(2)
    (1) Imperial Tobacco Ltd, Bristol, U.K.; (2) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    When the National Academies of Sciences released “Toxicity Testing in the 21st Century: A Vision and a Strategy” a new toxicological paradigm was created, focusing on the use of human cell lines and the disruption of key cellular pathways. In keeping...
  7. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 48

    The proposed use of human cells to cover the ‘R’ end point for EUTPD2 data requirements from a 21st century toxicology perspective

    SIMMS L.(1); PALMER J.(2)
    (1) Imperial Tobacco Limited, Bristol, U.K.; (2) Stemina, Madison, WI, U.S.A.
    In 2007 the National Academies of Sciences released “Toxicity Testing in the 21st Century: A Vision and a Strategy”, a new toxicological paradigm, moving away from the idea of high dose animal tests as the ‘gold standard’ and focusing on the use of...
  8. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 80

    The CORESTA recommended in vitro test battery alongside the National Research Council vision for toxicity testing in the 21st Century

    SIMMS L.(1); WIECZOREK R.(2); TRELLES STICKEN E.(2)
    (1) Imperial Tobacco Ltd, Bristol, U.K.; (2) Imperial Tobacco Group, Reemtsma Cigarettenfabriken GmbH, Biological Labs Hamburg, Hamburg, Germany
    The CORESTA In vitro Toxicity Testing of Tobacco Smoke Task Force recommended a test battery in 2004 which has been subsequently used by the tobacco industry. A similar in vitro test battery has been used by the International Community on...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2013, Seville, ST 19

    Human mouth-level transfer rate of menthol, 1.8-cineole and nicotine from Swedish pouched snus

    TROUDE V.(1); GADOIS-POMMEREUL S.(1); CLARKE A.(2); SIMMS L.(2)
    (1) SEITA, Imperial Tobacco Group, Fleury-les-Aubrais, France; (2) Imperial Tobacco Limited, Bristol, U.K.
    To facilitate the development of a transfer model which can be used to estimate human exposure to flavour and tobacco constituents, a human in vivo study involving 198 Swedish active snus users was conducted. All subjects agreed to participate in the...