Search Results

58 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 45

    Meta-analysis study to establish population level estimates of NNAL in smokers and non-smokers

    AYALA-FIERRO F.(1); VERRON T.(2); LIZHNYAK P.(3); FREELAND R.(4); FROST-PINEDA K.(4); ELAMIN A.(5); PRASAD G.L.(4); SARKAR M.(3)
    (1) Juul Labs, Inc, U.S.A.; (2) Imperial Brands, U.K.; (3) Altria Client Services, U.S.A.; (4) RAI Services Company, U.S.A.; (5) Philips Morris International, Switzerland
    The purpose of this research (a project of the CORESTA Biomarkers Sub-Group) was to establish a population level estimate for the biomarker of cigarette smoke exposure, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), to serve as a baseline...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 47 (also presented as poster at TSRC 2021)

    Biomarkers of potential harm in smoking abstinence and in the use of Vuse electronic nicotine delivery systems (ENDS)

    MAKENA P.; SCOTT E.; CHEN P.; LIU H-P.; JONES B.A.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, U.S.A.
    Qualified biomarkers of potential harm (BoPH) are useful in evaluating the beneficial effects of abstinence from cigarette smoking or switching to potentially reduced risk tobacco products. We benchmarked BoPH changes in a 14-day smoking abstinence...
  3. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 21

    Characterization of free radicals in cigarette smoke and e-cigarette aerosols by spin-trapping EPR spectroscopy

    DAVIS M.(1); PROBERT C.C.(2); SMIRNOVA T.(2); SMIRNOV A.(2); PRASAD G.L.(3)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) North Carolina State University, Raleigh, NC, USA; (3) RAI Services Company, Winston-Salem, NC, USA
    E-cigarettes have gained popularity since their introduction in the market; however, only limited data about free radical content of e-cigarette aerosols and the nature of the radicals formed are available in the literature. The overall goal of this...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 45

    Meta-analysis of two biomarkers of exposure of tobacco products

    AYALA-FIERRO F.(1); ELAMIN A.(2); FROST-PINEDA K.(3); JIN T.(3); PRASAD G.L.(3); SARKAR M.(4); SCHMIDT E.(3); VERRON T.(5)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) Altria Client Services LLC, Richmond, VA, U.S.A.; (5) SEITA - Imperial Brands, Paris, France
    In the context of tobacco products, broadly two types of biomarkers exist, biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH). BoE measure exposure to tobacco constituents, e.g. carbon monoxide (CO) and nicotine equivalents (NEQs)....
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 50 (also presented at TSRC 2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, U.S.A.
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and chronic obstructive pulmonary disease (COPD). One of the key functions of lung epithelial cells is to serve as a physical barrier against insults...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 51

    Structural investigation of the tobacco specific urinary biomarker iPX

    SCHMIDT E.; PRASAD G.L.
    RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.
    Biomarkers of potential harm (BoPH) are tools to assess biological and pathophysiological effects associated with chronic tobacco product use, such as oxidative stress. Isoprostanes are widely recognized as BoPH for assessing endogenous oxidative...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 52 (also presented at TSRC 2019)

    A blood-based smoking-related gene expression signature using a machine learning approach

    LIU G.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Smoking is a leading risk factor in the onset of multiple forms of cancer, chronic obstructive pulmonary disease, and cardiovascular disease. At present, there is a limited understanding by which changes in gene expression profiles in blood or other...
  8. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 015

    Levels of endothelial progenitor cells (EPCs) in smokers and moist snuff consumers

    ARIMILLI S.(1); CHEN P.(2); PRASAD G.L.(2)
    (1) Eurofins Professional Scientific Services, Winston Salem, NC, USA; (2) RAI Services Company, Winston Salem, NC, USA
    Endothelial progenitor cells (EPCs) are a key cell type present in circulation and are reported to play a role in the development of cardiovascular diseases. EPCs are derived from the bone marrow and mediate the differentiation, regeneration and...
  9. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 030

    Identification of predictive clinical biomarkers for developing chronic obstructive pulmonary disease using real world evidence data

    LIU GANG M.; MAKENA P.; HONG Kyung Soo; SCOTT E.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, USA
    Identification of predictive biomarkers and quantification of individual risk for developing smoking-associated diseases such as Chronic Obstructive Pulmonary Disease (COPD) aids in evaluating and predicting the health effects from tobacco products....