Search Results

11 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 44

    Lung biomarkers of harm/effect for tobacco regulatory research: opportunities and challenges – a literature review

    MAKENA P.(1); EDMISTON J.(2); BEATTIE E.(3); MASON E.(4); McEWAN M.(5); PRASAD K.(5)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.; (3) Cliantha Research Limited, Canada; (4) Imperial Brands PLC, Bristol, U.K.; (5) British American Tobacco (Investments) Limited, Southampton, U.K.
    Biomarkers of potential harm (BoPH) are indicators of biological perturbations in response to smoking, which may contribute to smoking-related disease. In this review, a project of the CORESTA Biomarkers Sub-Group, we critically assessed the...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 55

    An open-label, parallel-group, controlled study to evaluate changes in biomarkers of cigarette smoke exposure and biomarkers of potential harm in adult smokers who completely switch to using e-vapor products for 24 weeks

    EDMISTON J.; OLIVERI D.; LIANG Q.; SARKAR M.
    Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    The purpose of this study was to characterize biomarkers of exposure (BoE) to select harmful or potentially harmful components (HPHCs) and biomarkers of potential harm (BoPH) in adult smokers (AS) who switched to exclusive use of e-vapor products...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 043

    An open-label, randomized, parallel-group, controlled study to evaluate changes in biomarkers of cigarette smoke exposure and biomarkers of potential harm in adult smokers who completely switch to using e-vapor products for 12 weeks

    EDMISTON J.; OLIVERI D.; LIANG QIWEI; SARKAR M.
    Altria Client Services, Richmond, VA USA
    The purpose of this study was to characterize biomarkers of exposure (BOE) to select HPHCs and biomarkers of potential harm (BOPH) in adult smokers (AS) who switched to exclusive use of e-vapor products (EVPs) for 12 weeks. Method: Generally healthy...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 23

    Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – clinical study design

    SCHERER M.(1); LANDMESSER A.(1); PLUYM N.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) are becoming an accepted alternative to conventional cigarettes among smokers. Despite the increasing popularity of EVPs, little information exists on the fate of the main ingredients glycerol (G), propylene glycol (PG) and...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 24

    Biomarkers of exposure specific to e-vapour products based on stable-isotope labelled ingredients – results

    PLUYM N.(1); LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) consumption has steadily increased worldwide over the past decade. Ever since their introduction, there have been discussions about the potential health risks of EVPs in the scientific and public health community. These...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 42

    Identification of candidate biomarkers of tobacco related diseases through gene/disease associations

    EDMISTON J.(1); JESSEN W.(2); GOMATHINAYAGAM S.(3); REES W.(1); SARKAR M.(1)
    (1) Altria Client Services LLC, Center for Research and Technology, Richmond, VA 23219, U.S.A.; (2) Laboratory Corporation of America, Greenfield, IN, U.S.A.; (3) Covance Greenfield Laboratories, Greenfield, IN, U.S.A.
    Biomarkers can be useful tools in measuring the biological effects of tobacco product use. Although there is a small group of biomarkers that are typically used to assess the biological effect of tobacco use, there are few publications summarizing...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 43

    Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – methods

    SCHERER M.(1); LANDMESSER A.(1); PLUYM N.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) are becoming an accepted alternative for nicotine delivery amongst smokers. The popularity of EVPs has been increasing and more systematic research is required in order to assess the impact of e-cigarette use-related exposure...
  8. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 21 (also presented at TSRC 2016)

    Characterization of puff topography during 8-hours of ad libitum use of MarkTen® e-vapor products

    EDMISTON J.; LIANG Q.; VANSICKEL A.; LIU J.; ZHAO Y.; SARKAR M.
    (1) Altria Client Services LLC, Research, Development and Regulatory Affairs, Richmond, VA, U.S.A.; (2) Eurofins Lancaster Laboratories, Lancaster, PA, c/o Altria Client Services LLC, Richmond, VA, U.S.A.
    Introduction: The purpose of this study was to characterize the puff topography variables following use of MarkTen® electronic cigarettes by adult conventional cigarette smokers [CS], adult cigarette and e-vapor dual users [DU] and adult exclusive...
  9. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 55 (also presented at CORESTA 2016)

    Characterization of puff topography during 8-hours of ad libitum use of MarkTen® e-vapor products

    EDMISTON J.(1); ZHAO Y.(2); LIANG Q.(1); VANSICKEL A.(1); LIU J.(1); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, VA, USA; (2) Eurofins Lancaster Laboratories PSS, c/o Altria Client Services LLC, Richmond, VA, USA
    Introduction: The purpose of this study was to characterize the puff topography variables following use of MarkTen® electronic cigarettes by adult conventional cigarette smokers [CS], adult cigarette and e-vapor dual users [DU] and adult exclusive...
  10. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 56

    Randomized controlled trial methodological considerations for evaluating exposure from cigarettes and e-vapor products use under ad libitum ambulatory conditions

    EDMISTON J.(1); ZHAO Y.(2); LIANG Q.(1); LIU J.(1); DUHON C.(1); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, VA, USA; (2) Eurofins Lancaster Laboratories PSS, c/o Altria Client Services LLC, Richmond, VA, USA
    Introduction: The purpose of this study was to understand methodological considerations for a randomized controlled trial (RCT) designed to evaluate exposure and product use in adult smokers (AS) using e-vapor products under ad libitum conditions....