Search Results

8 results

  1. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 16

    Abuse liability evaluation of two nicotine lozenges compared to combustible cigarettes and NRT lozenge in adult smokers

    CAMPBELL C.; JIN TAO; JONES B.; ROUND E.; SCHMIDT E.; BAXTER-WRIGHT S.
    RAI Services Company, Winston-Salem, NC 27101, USA
    To examine the abuse liability (AL) of two mint-flavored hard and soft dissolvable nicotine lozenges (NL), we conducted a two-arm, five-way crossover study in confinement with healthy smokers. Subjects participated in five daily test sessions (each...
  2. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 17

    Pharmacokinetic evaluation of e-liquid flavors in three vuse electronic nicotine delivery systems (ENDS)

    HONG Kyung Soo; DELUCA P.; JIN TAO; JONES B.; SCHMIDT E.; NELSON P.; ROUND E.
    RAI Services Company, Winston-Salem, NC 27101, USA
    The impact of flavors on ENDS product use and nicotine exposure is an important factor in product regulation. As such, we evaluated the nicotine pharmacokinetics (PK) for three ENDS products (Vuse Ciro, Vibe and Solo) across four flavor variants for...
  3. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 23

    Abuse liability evaluation of portioned oral nicotine products compared to combustible cigarettes and NRT gum in adult smokers

    JONES B.; CAMPBELL L.; PREVETTE K.; ROUND E.; SCHMIDT E.; BAXTER-WRIGHT S.
    RAI Services Company, Winston-Salem, NC, USA
    This study investigated subjective measures and nicotine pharmacokinetic characteristics of portioned oral nicotine pouch product (investigational products [IPs]) use among healthy adult smokers. Results from this 5-way crossover study are reported...
  4. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 71

    Abuse liability assessment of vuse alto electronic nicotine delivery system (ENDS) as compared to combustible cigarettes and nicotine replacement therapy (NRT) in adult smokers

    HONG Kyung Soo; DARNELL J.; SCHMIDT E.; BAXTER-WRIGHT S.; NELSON P.; ROUND E.
    RAI Services Company, Winston-Salem, NC, USA
    The assessment of abuse liability (AL) of Electronic Nicotine Delivery Systems (ENDS) is an important factor in tobacco product regulation. We conducted a randomized, open label, crossover study to assess elements of AL of Vuse Alto ENDS using...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 049

    Assessment of in vitro toxicity/genotoxicity of ends and combustible products

    JORDAN K.(1); BOMBICK B.(1); COOPER B.(1); LEVERETTE R.(1); SHUTSKY T.(1); WEST C.(1); STRASSER J.(1); ROUND E.(1); MARANO K.M.(1); MOMIN R.(2); TRIVEDI A.(2); WAGSTAFF W.(2); BRUCE S.(3); DAKOULAS E.(3); ROY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labstat International ULC, Kitchener, ON, Canada; (3) BioReliance Corp, Rockville, MD, USA
    In May 2016, the U.S. Food and Drug Administration Center for Tobacco Products (CTP) issued draft guidance for Premarket Tobacco Product Applications (PMTA) for Electronic Nicotine Delivery Systems (ENDS), which recommends inclusion of in vitro...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 28 (also presented at TSRC 2017)

    Nicotine pharmacokinetics of electronic cigarettes: experimental data and a review of the literature

    FEARON I.M.(1); ELDRIDGE A.(1); GALE N.(1); McEWAN M.(1); NELSON P.(2); ROUND E.(2); STILES M.(2)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) RAI Services Co., Winston-Salem, NC, U.S.A.
    E-cigarettes are battery-powered electronic devices from which users can inhale nicotine following its aerosolisation from a heated liquid solution. Some regulators and public health bodies consider e-cigarettes as potentially playing a major role in...
  7. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 088 (also presented at CORESTA SSPT2017)

    Nicotine pharmacokinetics of electronic cigarettes: experimental data and a review of the literature

    FEARON I.M.(1); ELDRIDGE A.(1); GALE N.(1); McEWAN M.(1); NELSON P.(2); ROUND E.(2); STILES M.(2)
    (1) British American Tobacco (Investments) Limited, Southampton, UK; (2) RAI Services Company, Winston-Salem, NC, USA
    E-cigarettes are battery-powered electronic devices from which users can inhale nicotine following its aerosolisation from a heated liquid solution. Some regulators and public health bodies consider e-cigarettes as potentially playing a major role in...