CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 43
In vitro micronucleus (MN) assay using TK6 cells: review of historical positive and negative control data
(1) Charles River Laboratories, Genetic and In Vitro Toxicology, Skokie, IL, U.S.A.; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond, VA, U.S.A.
TK6 human lymphoblastoid cells are widely used in the in vitro MN assay as a part of regulatory genotoxicity testing for pharmaceuticals, but have seen relatively limited use in testing of other test materials, including tobacco-related products. As...