Search Results

17 results

  1. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 20

    Nrf2 response to whole smoke and aerosol of two different tobacco product types in a 3D human airway model

    KEYSER B.M.(1); LEVERETTE R.(1); HOLLINGS M.(2); ROTHWELL E.(2); WERTMAN J.(1); MORGAN(1); FIELDS W.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labcorp Early Development Laboratories, Harrogate, North Yorkshire, UK
    The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, activated in human lung cells by cigarette smoke, regulates genes involved in the antioxidative stress response. Here, we evaluated the effect of cigarette whole smoke (3R4F...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 42

    Characterization of whole mainstream smoke/aerosol delivery within the Vitrocell® Ames 48 high throughput exposure module using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); SEYMOUR A.(2); HOLLINGS M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, U.K.
    The preferred means of assessing combustible or other aerosol-generating tobacco products in vitro is by direct exposure of cell cultures to freshly generated whole mainstream smoke/aerosols. This approach eliminates the fractionation of...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 049

    High throughput air liquid interface exposure modules: characterization of smoke/aerosol dosimetry and in vitro mutagenicity and cytotoxicity of two tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); HOLLINGS M.(2); SEYMOUR A.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Covance Laboratories, North Yorkshire, UK
    The utilization of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessments of freshly generated whole smoke/aerosol from combustible cigarettes and tobacco heating products (THPs), as well as electronic nicotine delivery...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 12 (also presented at TSRC 2018)

    Characterization of the Vitrocell® high throughput exposure modules using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(2); SEYMOUR A.(2); HOLLINGS M.(2); BOMBICK B.(1)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    The development of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessment of freshly generated whole smoke and aerosol from combustible and tobacco heating products (THP) as well as electronic nicotine delivery systems...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 13 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 1. Mouse lymphoma assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); LLOYD M.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from different tobacco and nicotine delivery products was assessed...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 14 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 2. In Vitro micronucleus assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); WHITWELL J.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support toxicological evaluations of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 014 (also presented at CORESTA 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 1. Mouse lymphoma assay

    LEVERETTE R.(1); BOMBICK B.(1); FOWLER K.(1); BREHENY D.(2); GACA M.(2); THORNE D.(2); CLEMENTS J.(3); LLOYD M.(3); McENANEY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) British American Tobacco (Investments) Ltd., Southampton, UK; (3) Covance Laboratories Ltd, Harrogate, UK
    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from different tobacco and nicotine delivery products was assessed...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 015 (also presented at CORESTA 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 2. In vitro micronucleus assay

    LEVERETTE R.(1); BOMBICK B.(1); FOWLER K.(1); BREHENY D.(2); GACA M.(2); THORNE D.(2); CLEMENTS J.(3); McENANEY S.(3); WHITWELL J.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) British American Tobacco (Investments) Ltd., Southampton, UK; (3) Covance Laboratories Ltd, Harrogate, UK
    In vitro studies have been widely used to support toxicological evaluations of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 016 (also presented at CORESTA 2018)

    Characterization of the Vitrocell® high throughput exposure modules using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(1); BOMBICK B.(1); HOLLINGS M.(2); SEYMOUR A.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Covance Laboratories Ltd, Harrogate, UK
    The development of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessment of freshly generated whole smoke and aerosol from combustible and tobacco heating products (THP) as well as electronic nicotine delivery systems...
  10. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 049

    Assessment of in vitro toxicity/genotoxicity of ends and combustible products

    JORDAN K.(1); BOMBICK B.(1); COOPER B.(1); LEVERETTE R.(1); SHUTSKY T.(1); WEST C.(1); STRASSER J.(1); ROUND E.(1); MARANO K.M.(1); MOMIN R.(2); TRIVEDI A.(2); WAGSTAFF W.(2); BRUCE S.(3); DAKOULAS E.(3); ROY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labstat International ULC, Kitchener, ON, Canada; (3) BioReliance Corp, Rockville, MD, USA
    In May 2016, the U.S. Food and Drug Administration Center for Tobacco Products (CTP) issued draft guidance for Premarket Tobacco Product Applications (PMTA) for Electronic Nicotine Delivery Systems (ENDS), which recommends inclusion of in vitro...