Search Results

379 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2021, Online, AP 33

    Identification and functional characterization of the pale yellow gene in tobacco

    GRUNDMANN L.(1); PRAMOD S.(2); ADAMS A.(2); FREDERICK J.(2); KAENEL A.(1); NOLL G.(1); XU D.(2); PRUEFER D.(1); LUSSO M.(2)
    (1) Fraunhofer IME, Münster, Germany; (2) Altria Client Services, Richmond, VA, U.S.A.
    The pale yellow (PY) trait in tobacco (Nicotiana tabacum L.) was first described in 1969 and was found to be controlled by a single dominant gene. Plants containing a PY gene show accelerated chlorophyll breakdown compared to wild type plants. In...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, NAM 02

    Application of biokinetic modelling for in vitro to in vivo extrapolation (IVIVE) in chemical risk assessment

    PAINI A.(1); WORTH A.(2)
    (1) esqLABs GmbH, Saterland, Germany; (2) European Commission Joint Research Centre (JRC), Ispra, Italy
    In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses,...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 19

    Substantial reductions in selected harmful or potentially harmful constituents in heated tobacco aerosol, compared to 1R6F reference cigarette smoke, correlate with substantially reduced in vitro toxicological outcomes

    CHAPMAN F.(1); TRELLES STICKEN E.(2); WIECZOREK R.(2); POUR S.J.(2); DETHLOFF O.(2); STEVENSON M.(1)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company, Hamburg, Germany
    Heated tobacco products (HTPs) form a category of nicotine-containing next generation products (NGPs) which show potential for tobacco harm reduction (THR). This is attributed to the absence of combustion in producing a HTP aerosol, which in turn...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 43

    Quantitative analysis of NNN in plasma: a suitable alternative to urinary determination to assess the exposure to this important toxicant

    PLUYM N.(1); SIBUL F.(1); JIN X.(2); EDMISTON J.(2); SARKAR M.(2); SCHERER G.(1); SCHERER M.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research & Technology, Richmond, VA, U.S.A.
    N-Nitrosonornicotine (NNN) is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Urinary NNN has often been used as a biomarker of exposure. However, urinary NNN excretion is highly variable, possibly due to...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 44

    Analysis of 3-hydroxybenzo[a]pyrene in urine as a biomarker of exposure for BaP in smokers and users of potentially reduced risk products

    RÖGNER N.; SCHERER M.; SCHERER G.; PLUYM N.
    ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany
    Benzo[a]pyrene (BaP), which is classified as a Group 1 carcinogen by the IARC, is formed during the incomplete combustion of organic matter, like tobacco smoke. Urinary 3-hydroxybenzo[a]pyrene (3-OH-BaP) is commonly assessed as a biomarker of BaP...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 49

    Assessment of alternative cell lines for adoption within the OECD TG 129 for cytotoxicity determination

    POUR S.J.(1); WIECZOREK R.(1); CZEKALA L.(2)
    (1) Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company, Hamburg, Germany; (2) Imperial Brands PLC, Bristol, U.K.
    Neutral red uptake assay (NRU), part of the in vitro CORESTA test “battery” is one of the most commonly used cytotoxicity assays for the evaluation tobacco and next generation products (NGPs). OECD TG 129 guideline for the NRU assay was...
  7. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 54

    Evaluation of gaseous phase nicotine in e-liquid nicotine salts in e-cigarette aerosols

    JONES T.(1,2); KINTNER S.(1,2); ARMWOOD S.(1,2); ILLIDGE B.(3); LU HUANGHAI(3); HARDMAN P.(3); PANI J.(2); RUAN CHUNHAI(1,2)
    (1) ITG Brands, Greensboro, NC, USA; (2) Imperial Brands-Lab Network, Hamburg, Germany; (3) Imperial Brands-Nerudia, Liverpool, UK
    Nicotine is a key component in many e-cigarette formulations and during the vaping process, nicotine exists in both the gaseous phase and aerosol phase. There are two type of vaping techniques- mouth-to lung (MTL) and direct-to-lung (DTL). The...
  8. CORESTA Congress, Online, 2020, Agronomy/Phytopathology Groups, AP 01

    Identification and verification of lncRNA against herbivores in Nicotiana attenuata

    JIN Jingjing(1,2); RAN Li(3); BALDWIN I.T.(2)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, P.R. China; (2) Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany; (3) Institute of Insect Sciences, Zhejiang University, Hangzhou, P.R. China
    Long noncoding RNAs (lncRNAs) have been shown to play important roles in various biological processes in plants, including defense against pathogens. However, it is still unknown whether lncRNAs mediate defense against herbivore attack. In order to...
  9. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 10

    Modular new product development in highly dynamic markets

    KÜCHENHOF J.(1); NIEBUHR G.(2); SCHMIDT R.(2); KESSLER M.(2); KRAUSE D.(1)
    (1) Hamburg University of Technology, TUHH, Institute for Product Devcelopment and Mechanical Enginnering Design (PKT), Hamburg, Germany; (2) Hauni Maschinenbau GmbH, Dev. Vaping Technologies, Hamburg, Germany
    The implementation of a new approach always poses some organizational challenges but can also offer unrecognized opportunities. The Integrated PKT-approach for Development of Modular Product Families has been successfully implemented to reduce the...
  10. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 12

    Thermal behaviour of tobacco pads for aerosol generation

    JAMALI A.(1); BÄUMKER E.(1); SABERI M.(1); PELZ U.(1); SHEER C.(2); KESSLER M.(2); SCHMIDT R.(2); GOLDSCHMIDTBÖING F.(1)
    (1) University of Freiburg, IMTEK, Design of Microsystems, Freiburg, Germany; (2) Hauni Maschinenbau GmbH, Vaping Technologies, Hamburg, Germany
    Aerosol generation by heating tobacco to temperatures well below the burning point is one attempt to reduce the health risk of tobacco products. However, due to the poor thermophysical properties of tobacco, it takes a considerable amount of time and...