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  1. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 25

    Human abuse liability assessment of tobacco and nicotine products: considerations to meet current regulatory recommendations

    BAXTER S.(1); VANSICKEL A.(2); SHERWOOD N.(3); CAMPBELL L.(1); KONG M.(4)
    (1) RAI Services Company, Winston Salem, NC, U.S.A.; (2) Altria Client Services, Richmond, VA, U.S.A.; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) Altasciences Clinical Research, Laval, QC, Canada
    The U.S. Food and Drug Administration (FDA) recommends that tobacco product manufacturers provide information regarding the abuse liability of tobacco and nicotine-containing products to support pre-market tobacco, modified risk tobacco product and...
  2. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 26

    Comparative risk assessment of heated tobacco product and electronic cigarette aerosols with cigarette smoke based on cancer potency and margin of exposure

    RODRIGO G.; JACCARD G.; TAFIN DJOKO D.; KORNELIOU A.; ESPOSITO M.; BELUSHKIN M.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    An average reduction of more than 90 % in concentrations of harmful and potentially harmful constituents (HPHCs; among given lists) has been observed in the aerosols of commercial heated tobacco products (HTPs) and electronic cigarettes (ECs)...
  3. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 27

    Cardiovascular, carcinogenic and reproductive effects of nicotine exposure: a narrative review of the scientific literature

    MARTINEZ J.; PRICE L.
    JT International SA, Geneva, Switzerland
    The emergence of new tobacco heating products and electronic nicotine delivery systems (ENDS) is changing the way humans are exposed to nicotine. The purpose of this narrative review is to provide a broad overview of published scientific literature...
  4. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, STPOST 05

    A screening method by gas chromatography–mass spectrometry for the quantitation of 33 aerosol constituents from a heat-not-burn tobacco product

    HOFER I.; GAUTIER L.; CORTES SAUTEUR E.; DOBLER M.; PYTHON A.; O’REILLY C.; GISI D.; TINGUELY E.; WEHREN L.; GARCÍA FIDALGO E.; CUKURCAM L.; HENNEMANN M.; MATERA R.; ROTA D.; SANTOS CH.; SEQUEIRA C.; EPARS T.
    Philip Morris Products S.A., PMI R&D, Neuchatel, Switzerland
    This screening method allows the quantitation of 33 compounds [phenol, o-cresol, m-cresol, p-cresol, catechol, resorcinol, hydroquinone, 1,3-butadiene, isoprene, benzene, acrylonitrile, toluene, pyridine, styrene, propylene glycol, menthol,...
  5. CROM Symposium, Online, 2020, CROM 01

    A consortium approach for consumer-reported outcome measures for assessing tobacco and nicotine-containing products

    ACQUADRO C.(1); AFOLALU E.F.(2); BLACK R.A.(3); CAHOURS X.(4); CHREA C.(2); CLERC E.(2); CURTIN G.(5); EVANS S.(6); GILES L.(7); MacCAFFREY S.(3); PARK H.(8); PRASAD K.(9); SARKAR M.(10); SHIFFMAN S.(11); WEI Lay(10)
    (1) ICON PLC, Lyon, France; (2) Philip Morris Products SA, Switzerland; (3) JUUL Labs, Inc., USA; (4) Imperial Brands, France; (5) RAI Services Company, USA; (6) Turning Point Brands, USA; (7) JT International SA, Switzerland; (8) KT&G Research Institute, Republic of Korea; (9) British American Tobacco, U.K.; (10) Altria Client Services, USA; (11) Pinney Associates, USA
    The continuum of risk of tobacco products is generally accepted among public health authorities, where combustible products like cigarettes are the most risky and noncombustible products are at the lower end of the continuum. Adult smokers (AS)...
  6. CROM Symposium, Online, 2020, CROM 03

    Use of qualitative research to ensure we measure what matters to users of tobacco and/or nicotine products

    AFOLALU E.F.(1); CLERC E.(1); ABETZ-WEBB L.(2); CHREA C.(1)
    (1) Philip Morris Products SA, Neuchatel, Switzerland; (2) Patient-Centered Outcomes Assessments, Ltd, Cheshire, UK
    Cigarette smoking has a profound impact not on only physiological health but also perceived health and quality of life. There is currently a public health focus on cigarette smokers who switch to alternative smoke-free tobacco and nicotine-containing...
  7. CROM Symposium, Online, 2020, CROM 05

    Establishing traceability of self-reported dependence measurement through the use of crosswalks

    SALZBERGER T.(1); CANO S.(2); ABETZ-WEBB L.(3); AFOLALU E.F.(4); CHREA C.(4); WEITKUNAT R.(4); ROSE J.(6)
    (1) WU Wien (University of Economics and Business), Institute for Statistics and Mathematics, Austria; (2) Modus Outcomes, UK; (3) Patient-Centered Outcomes Assessments, UK; (4) PMI R&D, Philip Morris Products S.A., Switzerland; (6) Rose Research Center, LLC, USA
    Measurement in the social sciences has been characterized by deficient justification and underdeveloped conceptual theories. Instruments supposed to measure the same measurand typically do not provide comparable measurements. From the perspective of...
  8. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, AP 37

    Metabolic and transcriptomic shifts during tobacco leaf post-harvest senescence

    BOVET L.; HILFIKER A.; BATTEY J.; SIERRO N.; GOEPFERT S.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Tobacco is harvested after plant flowering, when the leaf senescence is more or less visible depending on cultivars. Before the drying phase, current practices allow the senescence to proceed until the detached leaf becomes yellow. This yellowing...
  9. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, AP Sustainability Forum

    Agro-Phyto Sustainability Forum

    WILDE L.(1); PRIBIC V.(2); EVANS W.(3); ROYO E.(4); BARGIACCHI E.(5); COLARD S.(6)
    (1) twentyfifty Ltd, Frome, U.K.; (2) JT International S.A., Geneva, Switzerland; (3) Imperial Tobacco Limited, Durban, South Africa; (4) Philip Morris International, Cape Town, South Africa; (5) Consortium INSTM, Firenze, Italy; (6) CORESTA, Paris, France
    In 2015, the United Nations published 17 sustainable development goals and their corresponding targets to be achieved by 2030. Like other sectors, the tobacco and alternative product sectors are likely to impact most of the...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 02

    Comparative assessment of selected compounds yields in heated tobacco products

    JACCARD G.; TAFIN DJOKO D.; KORNELIOU A.; BELUSHKIN M.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    A diverse range of heated tobacco products (HTPs) has been introduced in a growing number of markets by different manufacturers. They generally differentiate from cigarettes by the absence of combustion and a significant reduction in the levels of...