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  1. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 32

    Consumers’ responses to communication materials of a novel heat-not-burn tobacco product

    CHREA C.(1); KALLISCHNIGG G.(2); SANDERS E.(3); BEACHER F.(4); MAGNANI P.(4); RAMAZZOTTI A.(4); WEITKUNAT R.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) ARGUS – Statistics and Information Systems in Environment and Public Health GmbH, Berlin, Germany; (3) Edward Sanders Scientific Consulting, Peseux, Switzerland; (4) Philip Morris International Management S.A. (PMI) (part of Philip Morris International group of companies), Lausanne, Switzerland
    Modified risk tobacco products (MRTPs) are defined by the U.S. Food and Drug Administration (FDA) as tobacco products that are sold or distributed for use to reduce harm or the risk of tobacco-related disease associated with commercially marketed...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 33

    Air quality assessment during indoor use of the Tobacco Heating System 2.2

    MITOVA M.; GOUJON GINGLINGER C.; ROTACH M.; MAEDER S.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    PMI’s heat-not-burn Tobacco Heating System 2.2 (THS 2.2) generates tobacco aerosol containing mainly water, glycerine and nicotine. To address public health concerns about the possible presence of polluting substances during indoor use of THS 2.2, a...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 63 (also presented at TSRC 2017)

    A computational model to characterize the Vitrocell® Cell Exposure System for evaluation of aerosols

    CASTRO N.(1); ROSTAMI A.(1); KUCZAJ A.(2,3); LUCCI F.(2); OLDHAM M.J.(1); PITHAWALLA Y.B.(1)
    (1) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (3) Multiscale Modeling and Simulation, Faculty EEMCS, University of Twente, Enschede, The Netherlands
    In vitro exposure systems can be used as tools for toxicological assessment of e-cigarette aerosols. The VITROCELL® exposure system is designed such that exposure of cell cultures to the aerosol occurs at the air/liquid interface, which is relevant...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 02

    Analysis of 20 elements in aerosols by inductively coupled plasma mass spectrometry (ICP-MS)

    GREMAUD M.; HOFER I.; MARCHESE A.; SEQUEIRA C.; LE BOUHELLEC S.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Metals are present in the aerosol of tobacco products and are known as harmful or potentially harmful compounds. The purpose of this study was to improve and re-validate an existing method for the determination of elements in smoke from cigarettes...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 26

    How do consumers use the candidate modified risk tobacco product (MRTP) tobacco heating system (THS): analysis of data from six countries

    ROULET S.(1); MAGNANI P.(1); KALLISCHNIGG G.(2); BADOGLIO S.(1); ACKERMANN K.(3); VEIT M.(3); DUGAN A.(4); GAGE C.(4); KANITSCHEIDER C.(5); APECECHEA M.(5); RAMAZZOTTI A.(1)
    (1) Philip Morris International Management S.A. (PMI), Lausanne, Switzerland; (2) ARGUS – Statistics and Information Systems in Environment and Public Health, Berlin, Germany; (3) FehrAdvice & Partners, Zurich, Switzerland; (4) Kantar Health LLC, New York, U.S.A.; (5) Kantar Health GmbH, Munich, Germany
    PMI conducted consumer studies in several countries for a candidate MRTP, the THS. THS is composed of a tobacco heating device which heats specially designed tobacco sticks. The purpose of these studies was to investigate how adult daily smokers...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 31

    Psychometric evaluation of the mCEQ applied to cigarettes and heat-not-burn products in the U.S. and Japan

    SALZBERGER T.(1); CANO S.(2); MAINY N.(3); CHREA C.(3); VANDYKE S.(3); HAZIZA C.(3); WEITKUNAT R.(3); ROSE J.(4)
    (1) University of Economics and Business, Vienna, Austria; (2) Scale Report, Stotfold, U.K.; (3) Philip Morris Products S.A., Neuchatel, Switzerland; (4) Rose Research Center, Raleigh, U.S.A.
    The modified Cigarette Evaluation Questionnaire (mCEQ) is a self-report instrument that assesses the reinforcing effects of smoking cigarettes from a smoker’s perspective. Conceptually, the mCEQ consists of three multi-item and two single-item...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 32

    Assessment of the total volatile organic compounds in indoor air during the use of a new heat-not-burn product

    THARIN M.; BIELIK N.; ROUGET E; ROTACH M.; GLABASNIA A.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    PMI is developing products that have the potential to present less risk of harm to smokers who switch to these products versus continued smoking. The tobacco heating system (THS) is one of these products based on a technology that heats the tobacco...
  9. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 044

    Assessing population health effects of tobacco product use for regulatory compliance: a comparison of available methods

    TEISCHINGER F.(1); POLAND B.(2)
    (1) JT International, Geneva, Switzerland; (2) Certara USA, Menlo Park, CA, USA
    The US FDA encourages use of statistical models to project effects of a new tobacco product on population health, for Modified Risk Tobacco Product Applications (MRTPAs) and Pre-Market Tobacco Applications (PMTAs). We review different methods chosen...
  10. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 070

    Genetic approaches and resources for enabling compliance to proposed NNN standards

    DEWEY R.E.(1); LEWIS R.S.(1); LU Jianli(1); BOVET L.(2); GOEPFERT S.(2); CAMPANONI P.(2)
    (1) North Carolina State University, Raleigh, NC, USA; (2) Philip Morris International, Neuchatel, Switzerland
    Tobacco-specific nitrosamines (TSNAs) are formed through the nitrosation of tobacco alkaloids. Over the past decade, we have demonstrated how altering the genetics of the tobacco plant can result in dramatic reductions in TSNA formation. This has...