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3595 results

  1. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 05

    Assessment of in vitro toxicities demonstrated by total particulate matter (TPM) generated from current market and research reference standard cigarettes using the Bhas-42 promotor cell transformation assay

    SHUTSKY T.(1); McRAE R.(1); SZELIGA K.(1); BRUCE S.(2); JORDAN K.(1)
    (1) Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, NC 27102, USA; (2) MilliporeSigma (BioReliance® Toxicology Testing Services), Rockville, MD 20850, USA
    The Bhas 42 cell transformation assay (CTA) has been used to complement standard in vitro testing of tobacco products for understanding downstream biological implications of genetic toxicological changes related to tumor promotion. Investigators have...
  2. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 06

    Analysis of (S)- and (R)-nicotine in commercial nicotine samples and e-liquids and (R)-nicotine pharmacology

    DULL G.M.(1); MOLDOVEANU S.C.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco, Winston-Salem, NC, USA
    Nicotine has been studied extensively because of its presence in tobacco products. Because of its chirality, nicotine can exist in two enantiomeric forms; however, the tobacco plant produces predominantly (S)-nicotine with only a trace of...
  3. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 07

    ENDS topography across multiple platforms in an ambulatory setting

    DULL G.M.; BAXTER-WRIGHT S.; DARNELL J.; KANOBE M.; NELSON P.; PREVETTE K.; SMITH J.
    RAI Services Co., 401 N. Main Street, Winston-Salem, NC 27102, USA
    Topography, in the context of puffing behavior, is a methodology that is used to understand how consumers use a product. The Product Use and Behavior (PUB) instrument is a research tool that can effectively measure actual Electronic Nicotine Delivery...
  4. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 08

    Trapping efficiency study of fine particulate aerosols in the pocket and phlip commercial personal handheld filtration devices

    GRIMM J.(1); WRIGHT D.(2); WERLEY M.S.(3); MCKINNEY W.J.(4)
    (1) Philter Labs Inc., El Cajon, CA, USA; (2) IBR Laboratories, Grass Lake, MI, USA; (3) Fairview Consulting, Fredericksburg, VA, USA; (4) McKinney Regulatory Science Advisors, Henrico, VA, USA
    Personal handheld filtration devices used in combination with conventional electronic nicotine delivery systems (ENDS) provide a convenient, and effective means to significantly lower environmental and bystander exposure to exhaled vapor. A growing...