Search Results

415 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 06 (also presented as poster at TSRC 2021)

    A statistical methodology integrating resampling techniques to evaluate public health impact after introduction of reduced-risks products in Japan

    LARROQUE S.; KUBOTA T.; CHARRIÈRE M.; SONNERAT D.; KIMURA Y.
    JT International SA, 8 Rue Kazem Radjavi, 1202 Geneva, Switzerland; Japan Tobacco Inc., Tokyo, Japan
    Statistical modelling methodologies to predict the impact of reduced-risk products (with the potential to reduce the public health risks associated with smoking, “RRP”), namely e-cigarettes and heated tobacco products, require many input parameters;...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 39

    Influence of antioxidant capacity on micronucleus induction by cigarette smoke in various mammalian cell lines

    HASHIZUME T.; YAMAMOTO H.; SHIBUYA K.; FUKUSHIMA T.
    Japan Tobacco Inc., R&D Group, Scientific Product Assessment Center, Yokohama, Kanagawa, Japan
    Several cell lines can be used in the in vitro micronucleus (MN) assay to evaluate the genotoxic potential of various chemicals. However, less information is available on cell types suitable for genotoxic assessment of cigarette smoke. Therefore, we...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 41

    Identification of a novel mode of action to induce micronuclei by 1-(4-methoxyphenyl)pent-1-en-3-one

    WATANABE T.; MUNAKATA S.; ISHII T.; SAITO J.; TOMOHIRO T.; HASHIZUME T.
    Japan Tobacco Inc., R&D Group, Scientific Product Assessment Center, Yokohama, Kanagawa, Japan
    Compounds that test positive in the in vitro micronucleus test (MNT) need to be followed-up with in vivo MNT. However, it is not uncommon for some compounds to test negative in in vivo MNT, which are “misleading positives” in in vitro MNT. The...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 42

    Method development of an in vitro waterpipe air-liquid interface exposure system

    GAFNER J.(1); MILLER-HOLT J.(1); FUKUSHIMA T.(2)
    (1) Scientific and Regulatory Affairs, JT International SA, Geneva, Switzerland; (2) Scientific Product Assessment Center, R&D Group, Japan Tobacco Inc., Kanagawa, Japan
    Waterpipe tobacco smoke (WTS) bubbles through water before being inhaled and is a complex mixture of particulate gases formed by the heating of tobacco, flavourings and humectants, usually using an external charcoal piece. To date, there are no...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 51

    In vitro evaluation of tobacco free nicotine pouches

    MILLER-HOLT J.(1); ABRAHAM I.(1); SAKIMURA M.(1); FUKUSHIMA T.(2); GAFNER J.(1)
    (1) Scientific and Regulatory Affairs, JT International SA, Geneva, Switzerland; (2) Scientific Product Assessment Center, R&D Group, Japan Tobacco Inc., Kanagawa, Japan
    Non-clinical in vitro studies were conducted to investigate the characteristics of tobacco free nicotine pouches alongside a reference snus product and marketed snus product. The investigation included the evaluation of nicotine transfer to...
  6. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 26 (also presented as presentation at CORESTA SSPT2021)

    A statistical methodology integrating resampling techniques to evaluate public health impact after introduction of reduced-risks products in Japan

    LARROQUE S.(1); KUBOTA T.(2); KIMURA Y.(2); CHARRIÈRE M.(1); SONNERAT D.(1)
    (1) JTI Geneva, Geneva Switzerland; (2) Japan Tobacco Inc., Tokyo, Japan
    Statistical modeling methodologies to predict the impact of reduced-risk products (with the potential to reduce the public health risks associated with smoking, “RRP”), namely e-cigarettes and heated tobacco products, require many input parameters;...
  7. CORESTA Congress, Online, 2020, Agronomy/Phytopathology Groups, AP 07

    The eIF(iso)4E-T deficient va tobacco is superior to Virgin A Mutant in resistance to Potato Virus Y

    TAKAKURA Y.; UDAGAWA H.; SHINJO A.; KOGA K.
    Japan Tobacco Inc., Leaf Tobacco Research Center, Oyama, Tochigi, Japan
    Potato Virus Y (PVY) infects tobacco (Nicotiana tabacum), inducing vein necrosis and thereby causing yield and quality losses. Tobacco strains with va locus (deletion of Va that includes eIF4E1-S), for example Virgin A Mutant (VAM) and TN90, show...
  8. CORESTA Congress, Online, 2020, Agronomy/Phytopathology Groups, AP 28

    Correlation between post-curing TSNA increase and alkaloid and nitrite contents in cured leaves

    KAWANA M.; MASUDA S.; SATO N.
    Japan Tobacco Inc., Leaf Tobacco Research Center (LTRC), Oyama, Tochigi, Japan
    Alkaloids and nitrite in tobacco leaves are known to be involved in the formation of tobacco-specific nitrosamines (TSNA). The formation is affected greatly by environmental conditions during curing and post-curing stages such as storage. To...